A-Migel 2% w/w (Oral Gel)
15 gm tube: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Acme laboratories ltd |
Indications
- Treatment of oral and gastrointestinal candidiasis
- Eradication of fungal colonization
- Treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses
- Treatment of Tinea pedis (Athlete's foot)
- Treatment of Tinea corporis (Tinea circinata)
- Treatment of Tinea manuum
- Treatment of Tinea cruris
- Treatment of Candidial infections
- Treatment of Tinea versicolor
- Treatment of skin infections
- Treatment of intertrigo
- Treatment of perianal infections
- Treatment of stomatitis angularis (cheilitis)
- Treatment of balanoposthitis
- Treatment of otitis externa
Pharmacology
- Antifungal activity against dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacteria
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption of fungal cell membrane
- Leakage of essential constituents from fungal cells
- Systemic absorption after oral gel administration
- Plasma protein binding
- Metabolism of absorbed Miconazole
- Excretion in urine
- Terminal plasma half-life of 20-25 hours
- Similar elimination half-life in renal impaired patients
Dosage
- Miconazole Oral Gel:
- Dosage for oropharyngeal candidosis
- Infants dosage (4-24 months)
- Adults and children dosage (2 years and older)
- Dosage for gastrointestinal tract candidosis
- Missed dose instructions
- Miconazole Cream:
- Application instructions for affected areas
- Early relief of symptoms (2 to 3 days)
- Clinical improvement timeline
- Duration of treatment for different infections
Administration
- Application to localized lesions
- Best results with prolonged contact with affected area
- Removal of dental prosthesis for oral candidosis
- Brushing dental prosthesis with the gel
Interaction
- Avoid concomitant treatment with Terfenadine, Astemizole and Cisapride
- Potential delay of Phenytoin and Cyclosporine metabolism
Contraindications
- Known hypersensitivity to the active ingredient
Side Effects
- Nausea and vomiting
- Diarrhea with long term use
- Rare allergic reactions
Pregnancy & Lactation
- Safety information during pregnancy
- Caution during lactation
Precautions & Warnings
- Monitoring of anti-coagulant effect
- Monitoring of phenytoin plasma level
- Caution in infants and young children
Overdose Effects
- Symptomatic and supportive treatment
- Possible vomiting and diarrhea
Therapeutic Class
- Aural Anti-fungal preparations
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children