Dakrin 2% w/w (Oral Gel)

Title

• Dakrin Oral Gel

Categories

• Oral Medication
• Antifungal Treatment
• Aural Anti-fungal Preparations

Description

• Indicated for the treatment of oral and gastrointestinal candidiasis
• Eradicates fungal colonization in the mouth and gastrointestinal tract
• Treats super infections due to gram-positive bacteria
• Indicated in dermatomycoses such as Tinea pedis, Tinea corporis, Tinea manuum, Tinea cruris, Candidial infections, Tinea versicolor, Infections of the skin, Perianal infections, Stomatitis angularis, Balanoposthitis, Otitis externa
• Has a rapid alleviating effect on pruritus that accompanies infection

Color Options

• Translucent

Pharmacodynamics

Inhibits demethylation step in ergosterol biosynthesis

Pharmacokinetics

Low oral bioavailability, systemically absorbed, bound to plasma proteins, primarily to serum albumin and red blood cells, undergoes significant metabolism, excreted unchanged in the urine

Dosage

• Infants 4-24 months: 1.25 ml (1/4 measuring spoon) of gel, applied 4 times a day after meals
• Adults and children 2 years of age and older: 2.5 ml (1/2 measuring spoon) of gel, applied 4 times a day after meals
• Infants (4 months of age or above), children, and adults who have difficulty swallowing tablets: dosage based on body weight, in four divided doses, with maximum daily dose not exceeding 250 mg four times daily
• Sufficient Miconazole Cream should be applied to cover affected areas twice daily (morning and evening) for certain conditions

Administration

Applied 2-4 times a day directly to the affected area with a clean finger, kept in contact with the affected area for at least a week after symptoms have disappeared, dental prosthesis should be removed at night and brushed with the gel for oral candidosis

Interaction

• Avoid concomitant treatment with Terfenadine, Astemizole, and Cisapride
• May delay Phenytoin and Cyclosporine metabolism

Contraindications

• Known hypersensitivity to the active ingredient

Side Effects

• Occasional nausea, vomiting, diarrhea with long-term use
• Rare allergic reactions

Pregnancy & Lactation

No information on safety during pregnancy, caution advised during nursing

Precautions & Warnings

• Monitoring anti-coagulant effect if used concomitantly
• Monitoring phenytoin plasma level if used concomitantly
• Avoid throat obstruction in infants and young children

Overdose Effects

May cause vomiting and diarrhea, treatment is symptomatic and supportive

Therapeutic Class

• Aural Anti-fungal Preparations

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of reach of children

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