Mizol 2% w/w (Oral Gel)
15 gm tube: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Medicon pharmaceuticals ltd |
Indications
- Treatment of oral and gastrointestinal candidiasis
- Eradication of fungal colonization
- Treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses like Tinea pedis, Tinea corporis, Tinea manuum, Candidial infections, Tinea versicolor, etc.
Pharmacology
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Low oral bioavailability (25-30%)
- Systemic absorption after administration as oral gel
- Metabolism of absorbed portion
- Plasma half-life of 20-25 hours
- Similar elimination half-life in renal impaired patients
Dosage
- Specific dosages for infants (4-24 months)
- Specific dosages for adults and children (2 years and older)
- Recommended dosage for oropharyngeal and gastrointestinal candidosis
- Missed dose instructions
- Application instructions for Miconazole Cream
- Early relief of symptoms in 2-3 days
- Lesions disappearance after 2-5 weeks
- Prolonged treatment for prevention of relapse
Administration
- Application to affected area 2-4 times a day
- Direct application to localized mouth lesions
- Removal of dental prosthesis at night during treatment
Interaction
- Avoid concomitant treatment with Terfenadine, Astemizole, and Cisapride
- Potential delay in Phenytoin and Cyclosporine metabolism
Contraindications
- Known hypersensitivity to the active ingredient
Side Effects
- Occasional nausea and vomiting
- Diarrhea with long-term use
- Rarely allergic reactions
Pregnancy & Lactation
- No information on safety during pregnancy
- Caution in nursing women due to potential excretion in human milk
Precautions & Warnings
- Monitoring of anticoagulant effect when used concomitantly
- Monitoring of phenytoin plasma level when used concomitantly
- Caution in infants and young children to prevent throat obstruction
Overdose Effects
- Accidental overdosage may cause vomiting and diarrhea
- Symptomatic and supportive treatment
- No specific antidote available
Therapeutic Class
- Aural Anti-fungal preparations
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children