Mycon 2% w/w (Oral Gel)
15 gm tube: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Aristopharma ltd |
Title
- Mycon Oral Gel
Categories
- Aural Anti-fungal preparations
Description
- Mycon oral gel is indicated for the treatment of oral and gastrointestinal candidiasis, eradication of fungal colonization in the mouth and gastrointestinal tract, and treatment of super infections due to gram-positive bacteria. It is also indicated in dermatomycoses such as Tinea pedis, Tinea corporis, Tinea manuum, Candidial infections, Tinea versicolor, infections of the skin, perianal infections, stomatitis angularis, balanoposthitis, and otitis externa.
Dimensions
- N/A
Color Options
- N/A
Functions
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption in production of ergosterol, causing holes to appear in the fungal cell membrane, leading to cell death
Materials
- N/A
Technical Specifications
- Low oral bioavailability (25-30%)
- Systemically absorbed with little absorption from the intestinal tract
- Plasma protein binding (88.2%) primarily to serum albumin and red blood cells (10.6%)
- Metabolized with less than 1% excreted unchanged in the urine
- Terminal plasma half-life of 20-25 hours
- Similar elimination half-life in renal impaired patients
Design Elements
- N/A
Usability Features
- Dosage for infants 4-24 months: 1.25 ml (1/4 measuring spoon) of gel, applied 4 times a day after meals
- Dosage for adults and children 2 years of age and older: 2.5 ml (1/2 measuring spoon) of gel, applied 4 times a day after meals
- Dosage for infants (4 months of age or above), children, and adults who have difficulty swallowing tablets: 20 mg per kg body weight per day, in four divided doses
Indications
- For the treatment of oral and gastrointestinal candidiasis
- For eradication of fungal colonization in the mouth and gastrointestinal tract
- For the treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses such as Tinea pedis, Tinea corporis, Tinea manuum, Candidial infections, Tinea versicolor, infections of the skin, perianal infections, stomatitis angularis, balanoposthitis, and otitis externa
Pharmacology
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption in production of ergosterol, causing holes to appear in the fungal cell membrane, leading to cell death
Dosage
- For oropharyngeal candidosis: Infants 4-24 months: 1.25 ml (1/4 measuring spoon) of gel, applied 4 times a day after meals
- For oropharyngeal candidosis: Adults and children 2 years of age and older: 2.5 ml (1/2 measuring spoon) of gel, applied 4 times a day after meals
- Missed Dose: Apply the missed dose as soon as you remember or omit the missed dose in case of next dosing time
- Miconazole Cream: Application frequency and duration for different skin conditions
Administration
- Application of gel for localized lesions of the mouth 2-4 times a day directly to the affected area with a clean finger
- Removal of dental prosthesis at night and brushing with the gel for oral candidosis
Interaction
- Avoid concomitant treatment with Terfenadine, Astemizole, and Cisapride
- Monitor anti-coagulant effect and phenytoin plasma level when used concomitantly with Mycon
Contraindications
- Known hypersensitivity to the active ingredient
Side Effects
- Occasional nausea and vomiting, diarrhea with long-term use
- Rarely allergic reactions
Pregnancy & Lactation
- No information regarding safety during pregnancy
- Caution advised when administered to a nursing woman due to potential excretion in human milk
Precautions & Warnings
- Monitoring of anti-coagulant effect and phenytoin plasma level when used concomitantly
- Caution to avoid throat obstruction in infants and young children
Overdose Effects
- Accidental overdosage may cause vomiting and diarrhea
- Symptomatic and supportive treatment for overdose
Therapeutic Class
- Aural Anti-fungal preparations
Storage Conditions
- Store in a dry place away from light and heat
- Keep out of the reach of children