MIC 2% w/w (Cream)
10 gm tube: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Globe pharmaceuticals ltd |
Title
- MIC Oral Gel
Categories
- Medicine
- Oral Care
- Antifungal
Description
- MIC oral gel for the treatment of oral and gastrointestinal candidiasis
Indications
- Treatment of oral and gastrointestinal candidiasis
- Eradication of fungal colonization
- Treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses like tinea pedis, tinea corporis, tinea manuum, candidial infections, tinea versicolor, intertrigo, perianal infections, stomatitis angularis, balanoposthitis, otitis externa
Pharmacology
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption of fungal cell membrane leading to cell death
- Low oral bioavailability (25-30%)
- Systemic absorption after oral administration
- Plasma protein binding (88.2%)
- Metabolized absorbed portion
- Excretion in urine less than 1%
- Terminal plasma half-life: 20-25 hours
Dosage
- Dosage for oropharyngeal candidosis in infants, children, and adults
- Dosage for gastrointestinal tract candidosis in infants, children, and adults
- Application of miconazole cream to cover affected areas
- Application frequency for different skin conditions
- Duration of treatment for various infections
Administration
- Application method for localized lesions in the mouth
- Recommendation for keeping gel in contact with affected area
- Removal and cleaning of dental prosthesis for oral candidosis
Interaction
- Avoidance of concomitant treatment with Terfenadine, Astemizole, and Cisapride
- Possible delay in Phenytoin and Cyclosporine metabolism
- Potential for drug precipitation and toxicity
Contraindications
- Contraindication in patients with known hypersensitivity to miconazole
Side effects
- Occasional nausea and vomiting
- Diarrhea with long term use
- Rare allergic reactions
Pregnancy lactation
- No safety information during pregnancy
- Caution in nursing women due to potential drug excretion in human milk
Precautions warnings
- Monitoring of anticoagulant effect and phenytoin plasma level
- Caution in infants and young children to avoid throat obstruction
Overdose effects
- Possible vomiting and diarrhea in case of accidental overdosage
- Symptomatic and supportive treatment
- No specific antidote available
Therapeutic class
- Aural Anti-fungal preparations
Storage conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children