Mitigal 2% w/w (Cream)
10 gm tube: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Ad din pharmaceuticals ltd |
Indications
- Treatment of oral and gastrointestinal candidiasis
- Eradication of fungal colonization in the mouth and gastrointestinal tract
- Treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses such as Tinea pedis, Tinea corporis, Tinea manuum, Candidial infections, Tinea versicolor, intertrigo, perianal infections, stomatitis angularis, balanoposthitis, otitis externa
Pharmacology
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption of fungal cell membrane leading to cell death
- Low oral bioavailability (25-30%)
- Systemic absorption after oral gel administration
- Binding to plasma proteins (88.2%)
- Metabolism of absorbed portion
- Excretion in urine (less than 1%)
- Terminal plasma half-life (20-25 hours)
Dosage
- Oral gel dosage for infants, adults, and children
- Gastrointestinal tract candidosis dosage for infants, children, and adults
- Application of missed dose
- Cream application for various fungal infections
- Duration of treatment for different infections
Administration
- Application frequency for localized mouth lesions
- Instruction for keeping gel in contact with affected area
- Removal and brushing of dental prosthesis for oral candidosis
Interaction
- Avoidance of concomitant treatment with specific drugs
- Potential delay of certain drugs' metabolism leading to toxicity
Contraindications
- Hypersensitivity to the active ingredient
Side Effects
- Occasional nausea and vomiting
- Diarrhea with long term use
- Rare allergic reactions
Pregnancy & Lactation
- Caution in pregnant women due to lack of safety information
- Exercise caution when administered to nursing women
Precautions & Warnings
- Monitoring of anticoagulant effect if used concomitantly
- Monitoring of phenytoin plasma level when used concomitantly
- Caution in infants and young children to prevent throat obstruction
Overdose Effects
- Symptomatic and supportive treatment for accidental overdose
- No specific antidote available
Therapeutic Class
- Aural Anti-fungal preparations
Storage Conditions
- Storage in dry place away from light and heat
- Keep out of the reach of children