Terbex 250 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Terbinafine hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
- Terbex Tablet
- Terbex Granules
- Terbex Cream
- Terbex 1% Spray
Categories
- Antifungal Medication
- Topical Antifungal Treatment
Description
- Indicated for onychomycosis of toenail or fingernail
- Inhibits biosynthesis of Ergosterol
- Dosage for different types of fungal infections
- Inhibitor of the CYP450 2D6 isozyme
- Contraindicated in individuals with hypersensitivity to terbinafine
- Adverse events include gastrointestinal symptoms, liver test abnormalities, rashes, and taste disturbances
- Not recommended during pregnancy and lactation
- Rare cases of liver failure reported
- No clinical experience in pregnant women
- Not established safety and efficacy in pediatric patients
- Limited clinical experience regarding overdose
Dimensions
- Tablet - 250 mg
- Granules - 125 mg, 187.5 mg, 250 mg
- Cream - varies based on affected area
- 1% Spray - varies based on indication
Color Options
Functions
- Treatment of onychomycosis
- Inhibits ergosterol biosynthesis
- Fungicidal activity
- Inhibitor of CYP450 2D6 isozyme
Materials
Technical Specifications
- Inhibits biosynthesis of Ergosterol through Squalene Epoxidase enzyme inhibition
- Presence in breast milk of nursing mothers after oral administration
Design Elements
Usability Features
- Relief of clinical symptoms usually occurs within a few days
- Optimal clinical effect is seen some months after mycological cure and cessation of treatment
Dosage and Administration
- Tablet - once daily for 6 weeks for fingernail onychomycosis, once daily for 12 weeks for toenail onychomycosis
- Granules - varies based on body weight for up to 6 weeks
- Cream - once or twice daily for specific durations based on type of infection
- 1% Spray - once or twice daily for specific durations based on indication
Interaction
- Inhibitor of the CYP450 2D6 isozyme
- Co-administration with 2D6-metabolized drugs requires careful monitoring and may require dose reduction
Contraindications
- Hypersensitivity to terbinafine
Side Effects
- Gastrointestinal symptoms
- Liver test abnormalities
- Rashes
- Urticaria
- Pruritus
- Taste disturbances
- Idiosyncratic and symptomatic hepatic injury
- Serious skin reactions
- Severe neutropenia
- Thrombocytopenia
- Angioedema
- Allergic reactions
- Malaise
- Fatigue
- Vomiting
- Arthralgia
- Myalgia
- Hair loss
Pregnancy and Lactation
- Not recommended during pregnancy
- Terbinafine is present in breast milk of nursing mothers
Precautions and Warnings
- Discontinue treatment in case of progressive skin rash
- Not recommended for patients with chronic or active liver disease
- Pretreatment serum transaminase tests advised before taking terbinafine tablets
Pediatric Uses
- Safety and efficacy not established in pediatric patients
Use in the Elderly
- No evidence to suggest different dosages or side effects compared to younger patients
Overdose Effects
- Clinical experience limited
- Doses up to 5 gm (20 times therapeutic daily dose) taken without inducing serious adverse reactions
Therapeutic Class
- Other Antifungal Preparations
- Topical Antifungal Preparations
Storage Conditions
- Store in a cool and dry place
- Below 30°C
- Protect from light