Artem (15 mg+90 mg)/5 ml (Syrup)
60 ml bottle: ৳ 220.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Artemether lumefantrine |
| Company | Aexim pharmaceuticals ltd |
| Also available as |
Title
- Artemether and Lumefantrine Tablets
Categories
- Medicine
- Healthcare
- Pharmaceutical
Description
- This product contains a fixed ratio of Artemether and Lumefantrine for the treatment of acute, uncomplicated malaria infections. It is effective against drug-sensitive and drug-resistant Plasmodium falciparum, as well as recommended for malaria infections acquired in areas where parasites may be resistant to other antimalarials.
Dimensions
Tablet form
Color Options
N/A
Functions
- Treatment of acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum
- Stand by emergency treatment for travelers at risk of infection
- Inhibition of nucleic acid-protein synthesis within malarial parasites
Materials
- Artemether
- Lumefantrine
- Excipients
Technical Specifications
- Contains a fixed ratio of 1:6 parts of Artemether and Lumefantrine respectively
- Active against blood stages of Plasmodium vivax, but not active against hypnozoites
Design Elements
N/A
Usability Features
- Recommended dosage for adults and children varies based on body weight
- Should be taken with high-fat food or drinks such as milk
- Not to be used for prophylaxis or for the treatment of cerebral malaria or other severe manifestations of severe malaria
Storage
Keep below 30°C temperature, away from light & moisture
Indications
- Treatment and stand by emergency treatment for adults, children, and infants with acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum
- Recommended for malaria infections acquired in areas where parasites may be resistant to other antimalarials
- Stand by emergency treatment suitable for non-immune travelers at risk of infection who may be unable to obtain prompt medical attention within 24 hours
Pharmacology
- Artemether is a derivative of naturally occurring substance Artemisinin
- Lumefantrine is a synthetic racemic fluorine mixture belonging to the aryl amino alcohol family
- Both components act in the food vacuoles of malarial parasites, interfering with the conversion of haem to haemozin and inhibiting nucleic acid-protein synthesis within the parasites
Dosage&Administration
- Dosing regimen varies based on body weight, with a standard 3-day treatment schedule for adults and children weighing 35 kg and above
- Patients with acute malaria are recommended to take the dose with high-fat food or drinks such as milk
- Repeat dose should be taken in case of vomiting within 1 hour of administration
Interaction
- No specific interaction information available
Contraindications
- Hypersensitivity to any of the ingredients or excipients
- Severe malaria according to WHO definition
- First trimester of pregnancy
- Patients with a family history of prolonged QTc interval or sudden death
- Patients with known disturbance of electrolyte balance
- Patients taking drugs metabolized by CYP2D6 enzyme
SideEffects
- Well tolerated with most adverse effects of mild to moderate severity and duration
- Adverse effects may include hypersensitivity, headache, dizziness, sleep disorder, nausea, diarrhea, vomiting, rash, fatigue
Pregnancy&Lactation
- Contraindicated in the first trimester of pregnancy, and for breastfeeding women
- Breastfeeding should not resume before day 28 unless potential benefits outweigh the risk of treatment
Precautions&Warnings
- Not evaluated for prophylaxis or treatment of cerebral malaria or severe manifestations of severe malaria
OverdoseEffects
- In case of suspected overdose, symptomatic and supportive therapy should be given as appropriate
- ECG and blood potassium level should be monitored
TherapeuticClass
- Anti-malarial drugs