Amodis 400 mg (Tablet)
Unit Price: ৳ 1.70 (24 x 10: ৳ 408.00)
Strip Price: ৳ 17.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metronidazole |
| Company | Square pharmaceuticals plc |
| Also available as |
Form
- Tablet
- Suspension
- Vaginal Gel
- Suppository
- IV Infusion
Dosage Recommendations
- 200 mg tid for 7 days
- 800 mg in the morning and 1-2 gm at night for 2 days
- 2 gm as a single dose for 1 day
- 100 mg tid for children aged 7-10 yrs
- 50 mg tid for children aged 1-3 yrs
- 400-800 mg tid for 5-10 days for extra-intestinal & asymptomatic amoebiasis
- 500 mg once daily for children aged 1-3 yrs for giardiasis
- 200 mg tid for 3 days for acute ulcerative gingivitis
- 400 mg tid for 7 days for leg ulcers and pressure sores
- 800 mg initially and then 400 mg tid for 7 days for anaerobic infections
Indications
- Prevention of post-operative infections due to anaerobic bacteria
- Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, post-operative wound infections caused by anaerobes
- Urogenital trichomoniasis
- Bacterial vaginosis
- Amoebiasis (intestinal, extra-intestinal disease and symptomless cyst passers)
- Giardiasis
- Acute ulcerative gingivitis
- Anaerobically infected leg ulcers, pressure sores
- Acute dental infections due to anaerobic organisms
- Antibiotic-associated pseudomembranous colitis
Pharmacological Classification
Imidazole class of antibacterial drug, antiprotozoal agent
Mechanism of Action
Reduction of the 5-nitro group by anaerobes metabolically, interaction with DNA, bactericidal action
Interaction
- Disulfiram
- Alcohol
- Oral anticoagulant therapy (warfarin type)
- Lithium
- Cyclosporin
- Phenytoin or phenobarbital
- 5-Fluorouracil
- Busulfan
Contraindications
History of hypersensitivity to Metronidazole or other Nitroimidazole derivatives
Side Effects
- Metallic taste
- Nausea
- Vomiting
- Diarrhoea
- Drowsiness
- Rashes
Pregnancy & Lactation
- FDA Pregnancy Category: B
- Usage in Pregnancy: Only if clearly needed
- Excretion in Human Milk: Excreted in human milk, caution advised
Precautions & Warnings
- Compelling reasons for extended administration
- Hematological tests should be carried out regularly
- Monitoring for adverse reactions like peripheral or central neuropathy
- Administration with caution to patients with hepatic encephalopathy
Use in Special Populations
- Hepatic Impairment
- Renal Impairment
Overdose Effects
Symptoms may include vomiting, ataxia, slight disorientation. No specific antidote available
Therapeutic Class
Amoebicides, Anti-diarrhoeal Antiprotozoal
Storage Conditions
Store below 30°C, protected from light, out of reach of children, not for use post expiry date