Amotrex 400 mg (Tablet)
Unit Price: ৳ 1.70 (10 x 10: ৳ 170.00)
Strip Price: ৳ 17.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metronidazole |
| Company | Aci limited |
| Also available as |
Title
- Amotrex 400 mg Tablet
Categories
- Antibiotic
- Antiprotozoal
- Amoebicide
Dimensions
- Tablet
- Suspension
- Vaginal Gel
- Suppository
- IV Infusion
Color Options
Functions
- Treatment of post-operative infections
- Treatment of septicaemia
- Treatment of trichomoniasis
- Treatment of bacterial vaginosis
- Treatment of amoebiasis
- Treatment of giardiasis
- Treatment of gingivitis
- Treatment of anaerobic infections
- Surgical prophylaxis
Materials
- Metronidazole
Technical Specifications
- Metabolism of Metronidazole by anaerobes
- Interaction of reduced form of Metronidazole with DNA
- Dosage and administration guidelines
- No specific antidote for Amotrex overdosages
- No routine adjustment in the dosage of Amotrex for renal failure during intermittent peritoneal dialysis or continuous ambulatory peritoneal dialysis
Design Elements
Usability Features
- Prevention from viral, parasitic, and bacterial infections
Indications
- Prevention of post-operative infections
- Treatment of septicaemia
- Treatment of trichomoniasis
- Treatment of bacterial vaginosis
- Treatment of amoebiasis
- Treatment of giardiasis
- Treatment of gingivitis
- Treatment of anaerobic infections
- Surgical prophylaxis
Pharmacology
- Metronidazole belongs to the imidazole class of antibacterial drugs
- Classified as an antiprotozoal agent
- Reduction of 5-nitro group by anaerobes
- Interaction with DNA leading to bactericidal action
Dosage & Administration
- Dosage guidelines based on age and condition
- Recommended doses for Trichomoniasis, Intestinal amoebiasis, Extra-intestinal & Asymptomatic amoebiasis, Giardiasis, Acute ulcerative gingivitis, Acute dental infections, Bacterial Vaginosis, Leg ulcers and pressure sores, Anaerobic infections, Surgical prophylaxis
- Different dosages for adults and children
Interaction
- Interaction with Disulfiram
- Avoidance of alcoholic beverages and drugs containing alcohol during therapy
- Potentiation of anticoagulant effect with oral anticoagulant therapy
- Increased plasma levels of lithium
- Closely monitored serum cyclosporin and serum creatinine during co-administration with Cyclosporin
- Increased elimination of Amotrex with Phenytoin or phenobarbital
- Reduced clearance of 5-fluorouracil and increased toxicity
- Possible increase in plasma levels of busulfan when co-administered
Contraindications
- History of hypersensitivity to Metronidazole or other Nitroimidazole derivatives
Side Effects
- Metallic taste
- Nausea
- Vomiting
- Diarrhoea
- Drowsiness
- Rashes
Pregnancy & Lactation
- US FDA Pregnancy Category B
- Excretion in human milk
- Caution advised during pregnancy and lactation
Precautions & Warnings
- Regular hematological tests for extended administration
- Monitoring for adverse reactions such as neuropathy
- Caution in patients with hepatic encephalopathy
- Darkening of urine
Use in Special Populations
- Impairment in hepatic metabolism
- No dosage adjustment needed for renal impairment
- Efficient removal during haemodialysis
Overdose Effects
- Symptoms limited to vomiting, ataxia, and slight disorientation
- No specific antidote
- Symptomatic and supportive treatment for suspected massive overdosages
Therapeutic Class
- Amoebicides
- Anti-diarrhoeal
- Antiprotozoal
Storage Conditions
- Store below 30°C
- Protection from light
- Keep out of reach of children
- Do not use after expiry date
Common Questions
- Uses
- Side effects
- Improvement timeline
- Contraindications
- Safety during pregnancy
- Recommended dose limitations
FAQ Quick Tips
- Antibiotic and antiparasitic treatment
- Possible side effects like nausea and metallic taste
- Avoidance of alcohol during treatment
- Dose adjustment for liver disease