M-Dazole 200 mg (Tablet)

Title

M-Dazole 200 mg Tablet

Category

• Antibiotic
• Antiprotozoal
• Amoebicide
• Anti-diarrhoeal

Indications

• Prevention of post-operative infections due to anaerobic bacteria
• Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, post-operative wound infections caused by anaerobes
• Urogenital trichomoniasis
• Bacterial vaginosis
• Amoebiasis (intestinal, extra-intestinal disease, symptomless cyst passers)
• Giardiasis
• Acute ulcerative gingivitis
• Anaerobically infected leg ulcers, pressure sores
• Treatment of acute dental infections due to anaerobic organisms
• Antibiotic-associated pseudomembranous colitis

Pharmacology

Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. It interacts with DNA and gives bactericidal action.

DosageAdministration

• TabletSuspension:
  • TrichomoniasisAdultsChildrenOver10yrs:
    • 200 mg tid or 400 mg bid for 7 days
    • 800 mg in the morning and 1-2 gm at night for 2 days
    • 2 gm as a single dose for 1 days
  • IntestinalAmoebiasisAdultsChildrenOver10yrs: 800 mg tid for 5 days
  • Extra-intestinalAsymptomaticAmoebiasisChildren7-10yrs: 200-400 mg tid
• VaginalGel: One applicator full (approx. 5 grams containing approx. 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days
• SuppositoryAnaerobicInfectionsAdults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
• IVInfusionAdultsChildrenOver12yrs: Infuse 500 mg 8 hourly at a rate of 5 ml/minute. Maximum of 4 g should not be exceeded during a 24-hour period.

Interaction

• Disulfiram
• Alcohol
• Lithium
• Cyclosporin
• Phenytoin or phenobarbital
• 5-Fluorouracil
• Busulfan

Contraindications

Hypersensitivity to Metronidazole or other Nitroimidazole derivatives

SideEffects

• Metallic taste
• Nausea
• Vomiting
• Diarrhoea
• Drowsiness
• Rashes

PregnancyLactation

• USFDAPregnancyCategory: B
• Recommendation: Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.

PrecautionsWarnings

• Regular hematological tests recommended for longer duration usage
• Administer with caution to patients with hepatic encephalopathy
• May darken urine

SpecialPopulations

• HepaticImpairment:
  • Recommendation: Administer with caution to patients with hepatic encephalopathy. Daily dosage should be reduced to one third.
• RenalImpairment:
  • Recommendation: No routine adjustment in the dosage need be made. In patients undergoing haemodialysis, Metronidazole should be re-administered immediately after.

OverdoseEffects

Symptomatic and supportive treatment should be instituted in case of suspected massive overdosages.

TherapeuticClass

• Amoebicides
• Anti-diarrhoeal
• Antiprotozoal

StorageConditions

Store below 30°C. Keep protected from light. Keep out of the reach of children. Do not use later than the date of expiry.

CommonQuestions

• WhatIsIt: M-Dazole 200 mg Tablet is an antibiotic medication that prevents the growth of bacteria and parasites.
• Uses: Treats and prevents viral, parasitic, and bacterial infections. Controls infections in liver, skin, joints, brain, and respiratory tract.
• SideEffects: Diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness, mouth ulcer.
• ImprovementTime: 1-2 days
• Contraindications: Should not be used in conditions such as hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
• SafetyInPregnancy: Not recommended unless absolutely necessary
• RecommendedDose:
  • Treats bacterial and parasitic infections
  • May cause side effects like nausea, stomach upset, and metallic taste in the mouth

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