Mecozol 400 mg (Tablet)

Unit Price: ৳ 1.00 (100's pack: ৳ 100.00)

Medicine Details

Category Details
Generic Metronidazole
Company Amico laboratories ltd
Also available as
Mecozol 200 mg suspension

Title

Mecozol 400 mg Tablet

Categories

  • Antibiotic
  • Antiprotozoal
  • Amoebicide

Description

Mecozol 400 mg Tablet is an antibiotic medication that performs its action by preventing the growth of bacterias and parasites. It is used for the treatment and prevention from viral and parasitic infections. It also prevents bacterial infections such as cold, cough, flu and vaginal infections. It also controls liver, skin, joints, brain and respiratory tract infections.

Attributes

  • Indications:
    • Prevention of post-operative infections
    • Treatment of septicaemia
    • Bacteraemia
    • Peritonitis
    • Brain abscess
    • Pelvic abscess
    • Pelvic cellulitis
    • Urogenital trichomoniasis
    • Bacterial vaginosis
    • Amoebiasis
    • Giardiasis
    • Acute ulcerative gingivitis
    • Anaerobically infected leg ulcers
    • Pressure sores
    • Acute dental infections
    • Antibiotic associated pseudomembranus colitis
  • Pharmacology:
    • Member of the imidazole class of antibacterial drug
    • Antiprotozoal agent
    • 5-nitro group is reduced by anaerobes metabolically
    • Interacts with DNA for bactericidal action
  • Dosage & Administration:
    • Tablet and Suspension:
      • Trichomoniasis (Adults & Children over 10 yrs):
        • 200 mg tid or 400 mg bid for 7 days
        • 800 mg in the morning and 1-2 gm at night for 2 days
        • 2 gm as a single dose for 1 days
      • Trichomoniasis (Children):
        • Children 7-10 yrs: 100 mg tid
        • Children 3-7 yrs: 100 mg bid
        • Children 1-3 yrs: 50 mg tid
      • Intestinal amoebiasis (Adults & Children over 10 yrs):
        • 800 mg tid for 5 days
      • Intestinal amoebiasis (Children):
        • Children 7-10 yrs: 400 mg tid
        • Children 3-7 yrs: 200 mg qid
        • Children 1-3 yrs: 200 mg tid
      • Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs):
        • 400-800 mg tid for 5-10 days
      • Extra-intestinal & Asymptomatic amoebiasis (Children):
        • Children 7-10 yrs: 200-400 mg tid
        • Children 3-7 yrs: 100-200 mg qid
        • Children 1-3 yrs: 100-200 mg tid
      • Giardiasis (Adults & Children over 10 yrs):
        • 2 gm once daily for 3 days
      • Giardiasis (Children):
        • Children 7-10 yrs: 1 gm once daily
        • Children 3-7 yrs: 600-800 mg once daily
        • Children 1-3 yrs: 500 mg once daily
      • Acute ulcerative gingivitis:
        • 200 mg tid for 3 days
      • Acute dental infections:
        • 200 mg tid for 3-7 days
      • Bacterial Vaginosis:
        • 400 mg bid for 7 days
        • 2 gm as a single dose for 1 days
      • Leg ulcers and pressure sores:
        • 400 mg tid for 7 days
      • Anaerobic infections:
        • 800 mg initially and then 400 mg tid for 7 days
      • Surgical prophylaxis:
        • 400 mg tid started 24 hours before surgery for 1 days
    • Vaginal Gel:
      • One applicator full intravaginally once or twice a day for 5 days
    • Suppository:
      • Anaerobic Infections:
        • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
        • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose
      • Surgical Prophylaxis:
        • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g every 8 hours for high risk procedures
        • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg every 8 hours for high risk procedures
    • IV Infusion:
      • Adults and children over 12 years:
        • Infuse 500 mg 8 hourly at a rate of 5 ml/minute for 7 days
        • Maximum of 4 g not to be exceeded during a 24-hour period
      • Children under 12 years:
        • 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.
  • Interaction:
    • Disulfiram may cause psychotic reactions
    • Alcohol consumption should be avoided during therapy
    • Potentiation of the anticoagulant effect with Warfarin
    • Increased levels of lithium
    • Monitoring required for Cyclosporin
    • Increased elimination of Metronidazole with Phenytoin or Phenobarbital
    • Reduced clearance of 5-fluorouracil
    • Increased plasma levels of busulfan
  • Contraindications:
    • History of hypersensitivity to Metronidazole or other Nitroimidazole derivatives
  • Side Effects:
    • Metallic taste
    • Nausea
    • Vomiting
    • Diarrhoea
    • Drowsiness
    • Rashes
  • Pregnancy & Lactation:
    • Pregnancy Category: B
    • Recommendation: Use during pregnancy only if clearly needed. Caution required during lactation as it is excreted in human milk.
  • Precautions & Warnings:
    • Regular hematological tests if administered longer than recommended duration
    • Caution in patients with hepatic encephalopathy
    • May darken urine
  • Use in Special Populations:
    • Hepatic impairment:
      • Substantial impairment of clearance
      • Reduce dosage for hepatic encephalopathy
    • Renal impairment:
      • No reduction in dosage required
      • Efficient removal during haemodialysis
  • Overdose Effects:
    • Vomiting
    • Ataxia
    • Slight disorientation
    • Symptomatic and supportive treatment required
  • Therapeutic Class:
    • Amoebicides
    • Anti-diarrhoeal
    • Antiprotozoal
  • Storage Conditions: Store below 30°C, protected from light, and out of the reach of children. Do not use after the expiry date.
  • Commonly Asked Questions:
    • What is Mecozol 400 mg Tablet?: An antibiotic medication for preventing the growth of bacteria and parasites.
    • What are the uses of Mecozol 400 mg Tablet?: Treatment and prevention of viral, parasitic, and bacterial infections.
    • What are the side effects of Mecozol 400 mg Tablet?: Diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness, and mouth ulcer.
    • How long before improvement is seen?: 1 or 2 days may be required before improvement is observed.
    • Contraindications to Mecozol 400 mg Tablet?: Hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
    • Safety during pregnancy?: Use only if absolutely necessary.
    • Effectiveness of higher than recommended dose?: No, increased chances of side effects.

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