Menilet 400 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metronidazole |
| Company | Alco pharma ltd |
| Also available as |
Product Title
- Menilet 400 mg Tablet
Categories
- Antibiotic
- Antiprotozoal
- Amoebicide
- Anti-diarrhoeal
Description
Metronidazole is indicated in the treatment of various infections caused by bacteria and parasites such as post-operative infections, septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis, acute ulcerative gingivitis, anaerobically infected leg ulcers, dental infections, and more.
Dosage Forms
- Tablet
- Suspension
- Vaginal Gel
- Suppository
- IV Infusion
Dosage Instructions
- 200 mg tid or 400 mg bid for 7 days for adults with trichomoniasis
- 2 gm as a single dose for 1 day for children with trichomoniasis
- 800 mg tid for 5 days for adults with intestinal amoebiasis
- 2 gm once daily for 3 days for adults with giardiasis
- 400 mg tid for 7 days for adults with bacterial vaginosis
- 800 mg initially then 400 mg tid for 7 days for adults with anaerobic infections
- One applicator full of Metronidazole gel intravaginally once or twice a day for 5 days
- 1 g every 8 hours for 3 days, then 1 g every 12 hours for adults with anaerobic infections using suppository
- Infuse 500 mg 8 hourly for adults and children over 12 years during IV infusion
Pharmacological Class
- Imidazole class of antibacterial drug
- Antiprotozoal agent
Interaction Warnings
- Potential psychotic reactions when used with disulfiram
- Avoid alcohol consumption during therapy
- Potentiation of anticoagulant effect when used with oral anticoagulants
- Possible increase in plasma levels of lithium when used concomitantly
- Close monitoring required when co-administered with cyclosporin, phenytoin, phenobarbital, 5-fluorouracil, and busulfan
Contraindications
- Hypersensitivity to Metronidazole or other Nitroimidazole derivatives
Side Effects
- Metallic taste
- Nausea
- Vomiting
- Diarrhoea
- Drowsiness
- Rashes
Pregnancy Category
Category B; caution advised during pregnancy and lactation
Precautions
- Regular hematological tests recommended for extended use
- Caution in patients with hepatic encephalopathy
- May darken urine
Special Population Uses
- Caution in patients with hepatic impairment; reduced dosage recommended
- No routine adjustment in dosage required in patients with renal failure
Overdose Effects
- Symptoms limited to vomiting, ataxia, and slight disorientation
- No specific antidote
- Symptomatic and supportive treatment recommended
Therapeutic Class
- Amoebicides
- Anti-diarrhoeal Antiprotozoal
Storage Conditions
Store below 30°C, protect from light, keep out of reach of children, do not use after expiry date
Commonly Asked Questions
- Usage for bacterial, parasitic, and viral infections
- Information on uses, side effects, contraindications, pregnancy safety, and effectiveness
- Quick tips for safe usage
Indications
- Prevention of post-operative infections due to anaerobic bacteria
- Treatment of various infections such as septicaemia, trichomoniasis, amoebiasis, giardiasis, gingivitis, bacterial vaginosis, and anaerobically infected leg ulcers
Mode of Action
Reduction of 5-nitro group metabolically leading to interactions with DNA and bactericidal action
Interaction
- Disulfiram
- Alcohol
- Warfarin type oral anticoagulants
- Lithium
- Cyclosporin
- Phenytoin or phenobarbital
- 5-Fluorouracil
- Busulfan
Contraindications Information
Contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives
Pregnancy & Lactation Information
Category B pregnancy; caution required during pregnancy and lactation
Precautions & Warnings
- Regular hematological tests recommended for extended use
- Caution in patients with hepatic encephalopathy
- May darken urine
- Caution in patients with hepatic and renal impairment
Use in Special Populations Information
- Reduced dosage recommended in hepatic impairment
- No routine adjustment in dosage required in renal failure
Overdose Effects Information
Some symptoms include vomiting, ataxia, and slight disorientation; no specific antidote; symptomatic and supportive treatment recommended
Indications Information
Prevention and treatment of various infections caused by bacteria and parasites
Storage Conditions Information
Store below 30°C, protect from light, keep out of reach of children, do not use after expiry date