Metfil 400 mg (Tablet)
Unit Price: ৳ 1.00 (100's pack: ৳ 100.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metronidazole |
| Company | Bristol pharmaceuticals ltd |
Product Title
- Metfil 400 mg Tablet
Category
- Antibiotic
- Antiprotozoal
- Amoebicide
Pharmacological Class
- Imidazole class of antibacterial drug
- Antiprotozoal agent
Indications
- Prevention of post-operative infections due to anaerobic bacteria
- Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis
- Treatment of urogenital trichomoniasis
- Bacterial vaginosis
- Amoebiasis (intestinal and extra-intestinal)
- Giardiasis
- Acute ulcerative gingivitis
- Anaerobically infected leg ulcers and pressure sores
- Acute dental infections due to anaerobic organisms
Mode of Action
- Reduction of 5-nitro group by anaerobes leading to bactericidal action by interaction with DNA
Dosage & Administration
- Tablet and Suspension:
- Variable dosages for different conditions and age groups
- Vaginal Gel:
- One applicator full intravaginally once or twice a day for 5 days
- Suppository:
- Different dosages for adults and children
- IV Infusion:
- Specific dosage for adults and children
Interactions
- Disulfiram: Psychotic reactions reported concurrently
- Alcohol: Avoid due to potential disulfiram-like reaction
- Lithium: May increase plasma levels
- Cyclosporin: Requires close monitoring when co-administered
- Phenytoin or phenobarbital: Increased elimination of Metfil
- 5-Fluorouracil: Reduced clearance resulting in increased toxicity
- Busulfan: May increase plasma levels leading to toxicity
Contraindications
- Hypersensitivity to Metronidazole or other Nitroimidazole derivatives
Side Effects
- Metallic taste
- Nausea
- Vomiting
- Diarrhoea
- Drowsiness
- Rashes
Pregnancy & Lactation
- US FDA Pregnancy Category - B
- Caution advised during lactation
Precautions & Warnings
- Regular hematological tests recommended if administered for longer duration
- Caution advised for patients with hepatic encephalopathy
- Patients should be warned about darkening of urine
Use in Special Populations
- Dosage reduction needed in hepatic impairment
- No routine dosage adjustment in renal impairment
Overdose Effects
- Reported symptoms include vomiting, ataxia, and slight disorientation
Therapeutic Class
- Amoebicides
- Anti-diarrhoeal
- Antiprotozoal
Storage Conditions
- Store below 30°C
- Protected from light
- Keep out of reach of children
- Do not use after expiry date
Commonly Asked Questions
- Description of Metfil 400 mg Tablet
- Uses of Metfil 400 mg Tablet
- Side effects of Metfil 400 mg Tablet
- Time for improvement with Metfil 400 mg Tablet
- Contraindications to Metfil 400 mg Tablet
- Safety of Metfil 400 mg Tablet during pregnancy
- Effects of exceeding recommended dosage
- Quick tips for using Metfil 400 mg Tablet