Metryl 500 mg/100 ml (IV Infusion)

100 ml bottle: ৳ 85.50

Medicine Details

Indications

  • Prevention of post-operative infections due to anaerobic bacteria
  • Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess
  • Treatment of urogenital trichomoniasis
  • Treatment of bacterial vaginosis
  • Treatment of amoebiasis (intestinal, extra-intestinal disease)
  • Treatment of giardiasis
  • Treatment of acute ulcerative gingivitis
  • Treatment of anaerobically infected leg ulcers and pressure sores
  • Treatment of acute dental infections due to anaerobic organisms
  • Treatment of antibiotic-associated pseudomembranous colitis

Pharmacology

  • Metronidazole belongs to the imidazole class of antibacterial drugs
  • It is classified therapeutically as an antiprotozoal agent
  • The 5-nitro group of Metronidazole is reduced by anaerobes metabolically
  • The reduced form of Metronidazole interacts with DNA and provides bactericidal action

Dosage & Administration

  • Available in tablets, suspensions, vaginal gel, suppository, and IV infusion forms
  • Dosage varies for trichomoniasis, intestinal amoebiasis, extra-intestinal & asymptomatic amoebiasis, giardiasis, acute ulcerative gingivitis, acute dental infections, bacterial vaginosis, leg ulcers and pressure sores, anaerobic infections, surgical prophylaxis
  • Vaginal gel recommended dose is one applicator full intravaginally once or twice a day for 5 days
  • IV infusion should be administered at a rate of 5 ml/minute

Interactions

  • Potential interactions with disulfiram, alcohol, oral anticoagulants, lithium, cyclosporin, phenytoin/phenobarbital, 5-fluorouracil, busulfan

Contraindications

  • Contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives

Side Effects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

Pregnancy & Lactation

  • US FDA Pregnancy Category B
  • Caution advised during lactation

Precautions & Warnings

  • Regular hematological tests recommended if administered for longer than usual duration
  • Caution in patients with hepatic encephalopathy
  • Patients should be warned that Metronidazole may darken urine

Use in Special Populations

  • Dosage reduction recommended for patients with hepatic impairment
  • No routine adjustment in the dosage for patients with renal impairment

Overdose Effects

  • Reported symptoms include vomiting, ataxia, slight disorientation
  • No specific antidote

Therapeutic Class

  • Amoebicides
  • Anti-diarrhoeal
  • Antiprotozoal

Storage Conditions

  • Store below 30°C
  • Keep protected from light
  • Keep out of the reach of children
  • Do not use later than the expiry date

Common Questions

  • Uses of Metronidazole IV Infusion
  • Side effects of Metronidazole IV Infusion
  • Duration for improvement of conditions
  • Contraindications to Metronidazole IV Infusion
  • Safety during pregnancy
  • Effectiveness in higher than recommended dose

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