Metsina 200 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Metronidazole
Company Ibn sina pharmaceuticals ltd
Also available as
Metsina 400 mg tablet Metsina 500 mg injection

Brand Name

Metsina

Category

Medicine

Dosage Forms

  • Tablet
  • Suspension
  • Vaginal Gel
  • Suppository
  • IV Infusion

Indications

  • Prevention of post-operative infections due to anaerobic bacteria
  • Treatment of septicaemia, peritonitis, brain abscess
  • Treatment of urogenital trichomoniasis
  • Treatment of bacterial vaginosis
  • Treatment of all forms of amoebiasis
  • Treatment of giardiasis
  • Treatment of acute ulcerative gingivitis
  • Treatment of anaerobically infected leg ulcers
  • Treatment of acute dental infections due to anaerobic organisms
  • Treatment of antibiotic-associated pseudomembranous colitis

Pharmacology

Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.

Mode of Action

Prevents the growth of bacterias and parasites

Dosage and Administration

  • Tablet and Suspension:
    • Trichomoniasis: 200-800 mg daily for multiple days
    • Intestinal Amoebiasis: 400-800 mg daily for multiple days
    • Extra-intestinal & Asymptomatic Amoebiasis: 400-800 mg daily for 5-10 days
    • Giardiasis: 1-2 gm once daily for 3 days
    • Acute Ulcerative Gingivitis: 200 mg tid for 3 days
    • Bacterial Vaginosis: 400 mg bid for 7 days
    • Leg Ulcers and Pressure Sores: 400 mg tid for 7 days
    • Anaerobic Infections: 400-800 mg daily for 7 days
    • Surgical Prophylaxis: 400 mg tid started 24 hours before surgery
  • Vaginal Gel: One applicator full intravaginally once or twice a day for 5 days
  • Suppository:
    • Anaerobic Infections: Adults: 1 g every 8-12 hours for 3-6 days, Children: Dose based on age
  • IV Infusion:
    • Adults and children over 12 years: Infuse 500 mg 8 hourly, maximum 4 g per 24 hours
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours

Interactions

  • Disulfiram
  • Alcohol
  • Oral anticoagulant therapy
  • Lithium
  • Cyclosporin
  • Phenytoin or phenobarbital
  • 5-Fluorouracil
  • Busulfan

Contraindications

Patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives

Side Effects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

Pregnancy & Lactation

Category B. Caution advised during pregnancy and lactation.

Precautions & Warnings

  • Regular hematological tests recommended for longer usage
  • Caution in patients with hepatic encephalopathy
  • May darken urine

Use in Special Populations

  • Hepatic Impairment: Reduced dosage for hepatic encephalopathy patients
  • Renal Impairment: No reduction in dosage needed
  • Haemodialysis: Re-administered immediately after haemodialysis

Overdose Effects

Symptomatic and supportive treatment for overdosages

Therapeutic Class

Amoebicides, Anti-diarrhoeal, Antiprotozoal

Storage Conditions

Store below 30°C, protected from light, and out of reach of children

Common Questions

  • What is Metsina 200 mg/5 ml Suspension?: Antibiotic medication preventing the growth of bacterias and parasites
  • What are the uses of Metsina 200 mg/5 ml Suspension?: Treatment and prevention from viral and parasitic infections, bacterial infections such as cold, cough, flu, and vaginal infections
  • What are the side effects of Metsina 200 mg/5 ml Suspension?: Diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness, and mouth ulcer
  • How long do I need to use Metsina 200 mg/5 ml Suspension before I see improvement of my conditions?: 1-2 days for improvement
  • What are the contraindications to Metsina 200 mg/5 ml Suspension?: Conditions such as hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
  • Is Metsina 200 mg/5 ml Suspension safe to use when pregnant?: Not recommended unless absolutely necessary
  • Will Metsina 200 mg/5 ml Suspension be more effective if taken in more than the recommended dose?: No, higher dose increases the risk of side effects

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