Tricozyl 400 mg (Tablet)

Unit Price: ৳ 1.26 (100's pack: ৳ 126.00)

Medicine Details

Category	Details
Generic	Metronidazole
Company	Edruc limited
Also available as	Tricozyl 200 mg suspension

Title

Tricozyl 400 mg Tablet

Description

Tricozyl 400 mg Tablet is an antibiotic medication indicated for the prevention and treatment of various infections caused by bacteria, parasites, and amoeba, including post-operative infections, septicaemia, bacteraemia, trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis, and dental infections. It is also used for acute ulcerative gingivitis, anaerobically infected leg ulcers, pressure sores, and antibiotic-associated pseudomembranous colitis.

Color options

White

Dosage form

Tablet
Vaginal Gel
Suppository
IV Infusion

Dosage instructions

Tablet and suspension:
- Adults children over 10 yrs:
  - Trichomoniasis:
    - 200 mg tid or 400 mg bid for 7 days
    - 800 mg in the morning and 1-2 gm at night for 2 days
    - 2 gm as a single dose for 1 day
  - Intestinal amoebiasis: 800 mg tid for 5 days
  - Extra intestinal amoebiasis asymptomatic amoebiasis: 400-800 mg tid for 5-10 days
  - Giardiasis: 2 gm once daily for 3 days
  - Acute ulcerative gingivitis: 200 mg tid for 3 days
  - Acute dental infections: 200 mg tid for 3-7 days
  - Bacterial vaginosis:
    - 400 mg bid for 7 days
    - 2 gm as a single dose for 1 day
  - Leg ulcers pressure sores: 400 mg tid for 7 days
  - Anaerobic infections: 800 mg initially and then 400 mg tid for 7 days
  - Surgical prophylaxis: 400 mg tid started 24 hours before surgery for 1 day
  - Children:
    - Trichomoniasis:
      - 100 mg tid
      - 100 mg bid
      - 50 mg tid
    - Intestinal amoebiasis:
      - 400 mg tid
      - 200 mg qid
      - 200 mg tid
    - Extra intestinal amoebiasis asymptomatic amoebiasis:
      - 200-400 mg tid
      - 100-200 mg qid
      - 100-200 mg tid
    - Giardiasis:
      - 1 gm once daily
      - 600-800 mg once daily
      - 500 mg once daily
    - Acute ulcerative gingivitis:
      - 100 mg tid
      - 100 mg bid
      - 50 mg tid
    - Bacterial vaginosis: 7.5 mg/kg tid
    - Anaerobic infections: 7.5 mg/kg tid
    - Surgical prophylaxis: 7.5 mg/kg tid
- Vaginal gel: The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days.
- Suppository:
  - Anaerobic infections:
    - Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
    - Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose
  - Surgical prophylaxis:
    - Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures
    - Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures
- Iv infusion:
  - Adults children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute
  - Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute

Pharmacology

Metronidazole, the active ingredient in Tricozyl, belongs to the imidazole class of antibacterial drugs and is classified therapeutically as an antiprotozoal agent. It exerts its bactericidal action by interacting with DNA after being metabolically reduced by anaerobes.

Interaction

Disulfiram
Alcohol
Oral anticoagulant therapy (warfarin type)
Lithium
Cyclosporin
Phenytoin or phenobarbital
5-Fluorouracil
Busulfan

Contraindications

History of hypersensitivity to Metronidazole or other Nitroimidazole derivatives

Side effects

Metallic taste
Nausea
Vomiting
Diarrhoea
Drowsiness
Rashes

Pregnancy lactation

Pregnancy category: B
Usage in pregnant women: Should be used during pregnancy only if clearly needed
Excretion in human milk: Metronidazole have been shown to be excreted in human milk. Caution should be exercised when Metronidazole is administered to a nursing woman.

Precautions warnings

Regular hematological tests recommended for longer duration use
Caution in patients with hepatic encephalopathy
May darken urine

Special populations

Hepatic impairment: Tricozyl should be administered with caution to patients with hepatic encephalopathy. Daily dosage should be reduced in these patients.
Renal impairment:
- Elimination half life: Remains unchanged
- Haemodialysis: Tricozyl should be re-administered immediately after haemodialysis.
- Peritoneal dialysis: No routine adjustment in the dosage of Tricozyl need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD)

Overdose effects

Symptoms: Vomiting, ataxia, slight disorientation
Specific antidote: None. Symptomatic and supportive treatment advised for suspected massive overdosages.

Therapeutic class

Amoebicides
Anti-diarrhoeal
Antiprotozoal

Storage conditions

Store below 30°C. Keep protected from light. Keep out of the reach of children. Do not use later than the date of expiry.

Common questions

What is Tricozyl 400 mg Tablet?: An antibiotic medication that prevents the growth of bacterias and parasites
What are the uses of Tricozyl 400 mg Tablet?: Treatment and prevention of viral, parasitic, and bacterial infections
What are the side effects of Tricozyl 400 mg Tablet?: Diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness, mouth ulcers
How long do I need to use Tricozyl 400 mg Tablet before I see improvement of my conditions?: 1 or 2 days
What are the contraindications to Tricozyl 400 mg Tablet?: Hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
Is Tricozyl 400 mg Tablet safe to use when pregnant?: Not recommended for use in pregnant women unless absolutely necessary.
Will Tricozyl 400 mg Tablet be more effective if taken in more than the recommended dose?: No, may lead to increased chances of side effects.