Menida 400 mg (Tablet)

Unit Price: ৳ 1.00 (100's pack: ৳ 100.00)

Medicine Details

Category Details
Generic Metronidazole
Company Oyster pharmaceuticals ltd
Also available as
Menida 200 mg suspension

Title

  • Menida 400 mg Tablet

Categories

  • Antibiotic Medication
  • Antiprotozoal
  • Amoebicide
  • Anti-diarrheal

Description

  • Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.
  • Menida 400 mg Tablet is an antibiotic medication that performs its action by preventing the growth of bacterias and parasites. It is used for the treatment and prevention from viral and parasitic infections. It also prevents bacterial infections such as cold, cough, flu, vaginal infections, liver, skin, joints, brain, respiratory tract infections.

Indications

  • Prevention of post-operative infections due to anaerobic bacteria
  • Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, post-operative wound infections caused by anaerobes
  • Urogenital trichomoniasis
  • Bacterial vaginosis
  • Amoebiasis (intestinal, extra-intestinal disease and that of symptomless cyst passers)
  • Giardiasis
  • Acute ulcerative gingivitis
  • Anaerobically infected leg ulcers and pressure sores
  • Acute dental infections due to anaerobic organisms
  • Antibiotic associated pseudomembranous colitis

Pharmacology

  • Metronidazole is classified as an antiprotozoal agent that is metabolically reduced by anaerobes, interacts with DNA, and exhibits bactericidal action

Dosage and administration

  • Tablet and suspension:
    • Adults:
      • 200 mg tid or 400 mg bid for 7 days
      • 800 mg in the morning and 1-2 gm at night for 2 days
      • 2 gm as a single dose for 1 day
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
  • Vaginal gel: One applicator full of Metronidazole gel intravaginally once or twice a day for 5 days
  • Suppository:
    • Anaerobic Infections:
      • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
      • Children 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours
    • Surgical Prophylaxis:
      • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures
      • Children 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures
  • Iv infusion:
    • Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute

Interactions

  • Disulfiram
  • Alcohol
  • Lithium
  • Cyclosporin
  • Phenytoin or phenobarbital
  • 5-Fluorouracil
  • Busulfan

Contraindications

  • Patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives

Side effects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

Pregnancy and lactation

US FDA Pregnancy Category B. Caution should be exercised when administered to a nursing woman.

Precautions and warnings

  • Hematological tests, especially leucocyte count should be carried out regularly
  • Caution should be exercised in patients with hepatic encephalopathy
  • Patients should be warned that Menida may darken urine

Special populations

  • Hepatic impairment:
    • Menida should be administered with caution to patients with hepatic encephalopathy
    • The daily dosage should be reduced in the presence of advanced hepatic insufficiency
  • Renal impairment:
    • The elimination half-life of Metronidazole remains unchanged in the presence of renal failure
    • No routine adjustment in the dosage of Menida need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD)

Overdose effects

  • Vomiting
  • Ataxia
  • Slight disorientation

Therapeutic class

  • Amoebicides
  • Anti-diarrhoeal
  • Antiprotozoal

Storage conditions

Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.

Frequently asked questions

  • Uses: Menida 400 mg Tablet treats viral, parasitic, and bacterial infections
  • Contraindications: Should not be used in specific conditions like hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
  • Pregnancy safety:
    • Not recommended for use in pregnant women unless absolutely necessary
  • Effectiveness at recommended dose: Taking a higher than the recommended dose lead to increased chances of side effects
  • Quick tips:
    • May cause side effects like nausea, stomach upset, and a metallic taste in the mouth
    • Do not drink alcohol during or for 2-3 days after treatment with this medicine
    • Inform your doctor if you have liver disease
    • Menida takes 1 or 2 days before you see an improvement in your health conditions

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