Ornid 500 mg (Tablet)

Indications

• Amoebiasis
• Giardiasis
• Trichomoniasis
• Bacterial vaginosis

Pharmacology

• Active against protozoa and anaerobic bacteria
• Interacts with DNA to cause destruction of helical DNA structure
• Inhibition of protein synthesis
• Cell death in susceptible organisms

Dosage & Administration

• Adult dosage for Amoebiasis: 500 mg twice a day for 5 days
• Children dosage for Amoebiasis: 10-25 mg per kg body weight in two divided doses
• Adult dosage for Amoebic dysentery: 1.5 gm once a day for 3 days
• Children dosage for Amoebic dysentery: 40 mg per kg body weight, once a day for 3 days
• Adult dosage for Giardiasis: 1.5 gm once daily for 1-2 days
• Children dosage for Giardiasis: 40 mg per kg body weight for 2 days
• Dosage for Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days
• Bacterial vaginosis dosage: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days

Interaction

• Mild potential to cause disulfiramlike reactions
• May increase the risk of hemorrhage due to diminished hepatic metabolism when used with oral anticoagulants
• Decreases the clearance of 5-fluorouracil

Contraindications

• Previous hypersensitivity to Ornidazole and other nitroimidazoles
• Central nervous system disorders, particularly in epilepsy or in peripheral neuropathy

Side Effects

• Limited to the gastrointestinal tract (nausea, vomiting, epigastric pain)
• Central nervous system effects (dizziness, headache, lassitude)
• Leukopenia during therapy
• Adverse CNS effects - headache, dizziness, lassitude or somnolence, fatigue, weakness

Pregnancy & Lactation

• Should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate

Precautions & Warnings

• Prescribed with caution in patients with ataxia, vertigo, and mental confusion
• Blood dyscrasia namely mild leukopenia has been reported rarely during prolonged treatment
• Decision to discontinue therapy should depend upon the gravity of infection if leukopenia occurs

Use in Special Populations

• Renal Impairment: Give a supplemental dose (50% of the usual dose) before dialysis in haemodialysis patients
• Hepatic Impairment Severe: Double the interval between doses

Therapeutic Class

• Amoebicides
• Anti-diarrhoeal
• Antiprotozoal

Storage Conditions

• Store at room temperature
• Protect from light and moisture

Related Brands

• OR 500 mg (Tablet) - zenith-pharmaceuticals-ltd