T-zol 1 gm (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tinidazole |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Trichomoniasis
- Giardiasis
- Amebiasis
- Bacterial Vaginosis
Treatment Caused By
- Trichomonas vaginalis
- Giardia duodenalis
- Entamoeba histolytica
- Anaerobic bacteria
Prevention of Postoperative Infections Dosage Adult
2g approximately 12 hours before surgery
Prevention of Postoperative Infections Dosage Children
Data not available for children below 12 years
Trichomoniasis Dosage Adult
A single 2g oral dose with food
Trichomoniasis Dosage Partner Treatment
Partners of infected patients should be treated simultaneously
Giardiasis Dosage Adult
A single 2g dose with food
Giardiasis Dosage Pediatric
A single dose of 50 mg/kg (up to 2g) with food
Amebiasis Intestinal Dosage Adult
2g per day for 3 days with food
Amebiasis Intestinal Dosage Pediatric
50 mg/kg/day (up to 2g per day) for 3 days with food
Amebic Liver Abscess Dosage Adult
2g per day for 3-5 days with food
Amebic Liver Abscess Dosage Pediatric
50 mg/kg/day (up to 2g per day) for 3-5 days with food
Bacterial Vaginosis Dosage Non Pregnant Adult
- 2g once daily for 2 days with food
- 1g once daily for 5 days with food
Administration Instructions
Should be taken with food, during or immediately after meals
Pharmacology
Active against protozoa and anaerobic bacteria, damages DNA strands or inhibits DNA synthesis
Interaction Alcohol
Avoid during use and for 3 days afterward
Interaction Anticoagulants
May increase anticoagulant effects
Interaction Cyclosporine
May elevate levels, increasing risk of toxicity
Interaction Drugs inducing CYP3A4
May increase metabolism of T-zol
Contraindications
- Patients with blood dyscrasias
- Organic neurological disorders
- Known hypersensitivity to the compound
Side Effects Gastrointestinal
- Nausea
- Vomiting
- Anorexia
- Diarrhoea
- Metallic taste
Side Effects Hypersensitivity Reactions
- Skin rash
- Pruritis
- Urticaria
- Angioneurotic edema
Side Effects Others
- Headache
- Tiredness
- Furry tongue
- Dark urine
- Leukopenia
Pregnancy Category
Category C - potential benefit justifies the potential risk to the fetus
Precautions Neurological Disturbances
- Dizziness
- Vertigo
- Uncoordination
- Ataxia
Precautions Pregnancy Use
Contraindicated during first trimester, use in late stages requires benefits outweigh possible risk
Precautions Breastfeeding Use
Recommend interruption during therapy and for 3 days following last dose
Special Use Renal Impairment
Additional dose equal to half the usual dose at the end of haemodialysis
Therapeutic Class
Amoebicides
Storage Conditions
Store at room temperature & protected from light