Avloquin 250 mg (Tablet)

Unit Price: ৳ 1.32 (10 x 10: ৳ 132.00)

Strip Price: ৳ 13.20

Medicine Details

Category	Details
Generic	Chloroquine phosphate
Company	Aci limited
Also available as	Avloquin 50 mg syrup

Indications

Treatment of malaria
Prophylaxis and suppression of malaria
Treatment of amoebic hepatitis and abscess
Treatment of discoid and systemic lupus erythematosus
Treatment of rheumatoid arthritis

Composition

Tablet: Chloroquine Phosphate BP 250 mg (equiv. to approx. 150 mg of Chloroquine base)
Syrup: Chloroquine Phosphate BP 80 mg (equiv. to approx. 50 mg of Chloroquine base) per 5 mL

Pharmacology

4-aminoquinoline antimalarial and amoebicidal agent used for the suppression and cure of malaria. Mechanism of action against blood schizonts remains unclear.

Dosage & Administration

Doses expressed in terms of chloroquine base
Treatment of acute malaria attack: Adult: 25 mg per kg body-weight over 3 days
Clinical prophylaxis: Adult: 300 mg chloroquine base every 7 days
Hepatic amoebiasis: Adult: 600 mg base daily for two days
Systemic lupus erythematosus: 150 mg of base daily
Rheumatoid arthritis: Adult: 150 mg of base daily
Management of photoallergic reactions: Adult: 150 to 300 mg of base daily
Porphyria cutanea tarda: Adult: 75 mg of base 2-3 times per week for 6-18 months

Interaction

Exhibits interaction with drugs like neostigmine, pyridostigmine, antacids, cimetidine, quinine, mefloquine, metronidazole, ampicillin

Contraindications

Known or suspected chloroquine resistance in P. falciparum
Hypersensitivity
Retinal damage
Concurrent therapy with hepatotoxic drugs

Side Effects

Gastro-intestinal: Nausea, vomiting, diarrhoea
Psychological: Psychotic episodes, anxiety, personality changes
Visual disturbances: Blurred vision, difficulties in focusing, keratopathy, retinopathy
Haematological: Aplastic anaemia, agranulocytosis, thrombocytopenia, neutropenia
Others: Loss of hair, bleaching of hair pigment, bluish black pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, reduced hearing, nerve deafness, uromyopathy, myopathy

Pregnancy & Lactation

Avoid use during pregnancy except for malaria treatment when benefit outweighs the hazard. Potential for serious adverse reactions in nursing infants.

Precautions & Warnings

Examine eyes before starting long-term treatment
Visual disturbances may render patients unfit to take charge of vehicles or machinery
Care is necessary for patients with impaired liver or renal function, prophyria, psoriasis, or history of epilepsy
Observe patients with G6PD deficiency for haemolytic anaemia