Uniquin 250 mg (Tablet)
Unit Price: ৳ 1.00 (10 x 10: ৳ 100.00)
Strip Price: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Chloroquine phosphate |
| Company | Aexim pharmaceuticals ltd |
Indications
- Treatment of malaria
- Prophylaxis and suppression of malaria
- Treatment of amoebic hepatitis and abscess
- Treatment of discoid and systemic and systemic lupus erythematosus
- Treatment of rheumatoid arthritis
Composition
- Tablet: Each film coated tablet contains Chloroquine Phosphate BP 250 mg equiv. to approx. 150 mg of Chloroquine base
- Syrup: Each 5 mL contains Chloroquine Phosphate BP 80 mg equiv. to approx. 50 mg of Chloroquine base
Pharmacology
- 4-aminoquinoline antimalarial and amoebicidal agent
- Used for the suppression and clinical cure of malaria due to susceptible strains of Plasmodium falciparum, P. ovale, P. vivax, and P. malariae
- Rapidly acting blood schizontocide with some gametocytocidal activity
Dosage & Administration
- Doses are normally expressed in terms of chloroquine base
- Adults and children: 25 mg of chloroquine base per kg body-weight given over 3 days
- An oral dose equivalent to 300 mg chloroquine base is given every 7 days for about one week before, during, and for at least 4 weeks after exposure
- Suggested oral dose for discoid and systemic lupus erythematosus is 150 mg of base daily, reducing gradually once symptoms have been controlled
Interaction
- Exhibits interaction with drugs like neostigmine, pyridostigmine, antacids, kaolin, cimetidine, ranitidine, quinine, mefloquine, amodiaquine, artemisinin, metronidazole, ampicillin
Contraindications
- Known or suspected chloroquine resistance in P. falciparum
- Hypersensitivity
- Retinal damage
- Concurrent therapy with hepatotoxic drugs
Side Effects
- Nausea, vomiting, and diarrhea
- Psychotic episodes, anxiety, and personality changes
- Blurred vision and difficulties in focusing, keratopathy, retinopathy
- Aplastic anemia, agranulocytosis, thrombocytopenia, and neutropenia
- Loss of hair, bleaching of hair pigment, bluish black pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, reduced hearing, nerve deafness, uromyopathy, and myopathy
Pregnancy & Lactation
- The use of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the possible hazard
- A decision should be made whether to discontinue nursing or to discontinue the drug taking into account the importance of the drug to the mother
Precautions & Warnings
- The eyes should be examined before starting long-term treatment and should be monitored subsequently
- Visual disturbances may render patients unfit to take charge of vehicles or machinery
- Care is necessary in administering to patients with impaired liver or renal function or to those with porphyria, psoriasis, or a history of epilepsy
- Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency should be observed for hemolytic anemia during chloroquine treatment
Therapeutic Class
- Anti-malarial drugs
Storage Conditions
- Keep below 30°C temperature, away from light & moisture
- Keep out of the reach of children