Jasoprim 15 mg (Tablet)

Indications

• Prevention of relapse of vivax malaria

Pharmacology

• Eliminates exoerythrocytic forms of malarial parasite
• Disrupts mitochondria
• Binds to DNA
• Generates reactive oxygen species
• Interferes with electron transport in the parasite

Dosage

• Recommended for radical cure of vivax malaria
• Administered concurrently with chloroquine phosphate
• Dosage of 15mg base daily for 14 days

Administration

• Should be taken with food
• Take with meals to avoid gastrointestinal discomfort

Interaction

• Enhanced effect with drugs prolonging the QT interval

Contraindications

• Acutely ill patients with systemic diseases
• Concurrent use with potentially haemolytic drugs
• Concomitant administration with mepacrine

Side Effects

• Abdominal pain
• Gastric distress
• Nausea
• Vomiting
• Methaemoglobinaemia
• Haemolytic anaemia in G6PD deficiency
• Mild anaemia
• Leucocytosis
• Hypertension
• Cardiac arrhythmias
• Prolonged QT interval on ECG
• Accommodation disturbance
• Rarely, leucopenia and agranulocytosis

Pregnancy & Lactation

• Primaquine contraindicated in pregnant women
• Toxicity to reproduction in animal data
• Not known if excreted in human milk
• Potential for serious adverse reactions in nursing infants

Precautions & Warnings

• Patients with G6PD deficiency
• NADH methaemoglobin reductase deficiency
• Children
• Pregnancy and lactation

Overdose Effects

• Abdominal cramps
• Vomiting
• Burning epigastric distress
• Central nervous system and cardiovascular disturbances
• Cardiac arrhythmia and QT interval prolongation
• Cyanosis
• Methemoglobinemia
• Moderate leukocytosis or leukopenia
• Anemia
• Granulocytopenia and acute hemolytic anemia in G6PD deficient patients
• Patients recover completely if dosage is discontinued

Therapeutic Class

• Anti-malarial drugs

Storage Conditions

• Store at 25°C
• Protect from light

Related Brands

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