Kanaprim 15 mg (Tablet)
Unit Price: ৳ 1.38 (10 x 10: ৳ 138.00)
Strip Price: ৳ 13.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Primaquine phosphate |
| Company | Globe pharmaceuticals ltd |
Indications
- Prevention of relapse of vivax malaria
Pharmacology
- Antimalarial drug
- Eliminates exoerythrocytic forms of Plasmodium vivax
- Disrupts mitochondria and binds to DNA
Dosage
- Recommended for radical cure of vivax malaria
- Administered concurrently with chloroquine phosphate
- Dosage of 1 tablet (equivalent to 15 mg base) daily for 14 days
Administration
- Should be taken with food
- Take with meals to avoid GI discomfort
Interaction
- Enhanced effect with drugs that prolong the QT interval
Contraindications
- Contraindicated for acutely ill patients with systemic disease
- Concurrent use with potentially haemolytic drugs or depressants of bone marrow elements
- Concomitant admin with mepacrine
Side Effects
- Abdominal pain
- Gastric distress
- Nausea
- Vomiting
- Methaemoglobinaemia
- Haemolytic anaemia
- Leucocytosis
- Hypertension
- Cardiac arrhythmias
- Prolonged QT interval on ECG
- Accommodation disturbance
- Rarely leucopenia
- Agranulocytosis
Pregnancy & Lactation
- Pregnancy Category C
- Contraindicated in pregnant women
- Toxicity to reproduction shown in animal data
- Unknown excretion in human milk
- Consideration for nursing mothers
Precautions & Warnings
- Patient with G6PD deficiency
- NADH methaemoglobin reductase deficiency
- Childn
- Pregnancy and lactation
Overdose Effects
- Symptoms include abdominal cramps
- Vomiting
- Burning epigastric distress
- CNS and cardiovascular disturbances
- Cardiac arrhythmia
- QT interval prolongation
- Cyanosis
- Methemoglobinemia
- Moderate leukocytosis or leukopenia
- Anemia
- Granulocytopenia and acute hemolytic anemia in G6PD deficient patients
Therapeutic Class
- Anti-malarial drugs
Storage Conditions
- Store at 25° C
- Protect from light