P Phos 15 mg (Tablet)

Indications

• Radical cure of vivax malaria

Pharmacology

• 8-aminoquinoline antimalarial
• Eliminates exoerythrocytic forms of Plasmodium vivax, Plasmodium ovale, Plasmodium falciparum
• Disrupts mitochondria and binds to DNA
• Generates reactive oxygen species
• Interferes with electron transport in the parasite

Dosage

• Recommended for radical cure of vivax malaria
• Prevention of relapse in vivax malaria
• Following termination of chloroquine phosphate suppressive therapy
• Administered concurrently with chloroquine phosphate
• 1 tablet (equivalent to 15 mg base) daily for 14 days

Administration

• Should be taken with food
• Take with meals to avoid GI discomfort

Interaction

• Enhanced effect with other drugs that prolong the QT interval

Contraindications

• Acutely ill patients with systemic diseases
• Concurrent use with potentially haemolytic drugs
• Concomitant admin with mepacrine

Side Effects

• Abdominal pain
• Gastric distress
• Nausea
• Vomiting
• Methaemoglobinaemia
• Haemolytic anaemia
• Mild anaemia
• Leucocytosis
• Hypertension
• Cardiac arrhythmias
• Prolonged QT interval on ECG
• Accommodation disturbance
• Rarely leucopenia
• Agranulocytosis

Pregnancy & Lactation

• Category C for pregnancy
• Contraindicated in pregnant women
• Not known whether excreted in human milk

Precautions & Warnings

• Patient with G6PD deficiency
• NADH methaemoglobin reductase deficiency
• Childn
• Pregnancy and lactation

Overdose Effects

• Abdominal cramps
• Vomiting
• Burning epigastric distress
• CNS and cardiovascular disturbances
• Cardiac arrhythmia
• QT interval prolongation
• Cyanosis
• Methemoglobinemia
• Moderate leukocytosis or leukopenia
• Anemia
• Granulocytopenia
• Acute hemolytic anemia
• Recovery upon discontinuation of dosage

Therapeutic Class

• Anti-malarial drugs

Storage Conditions

• Store at 25°C
• Protect from light

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