Panamox 100 mg/5 ml (Oral Suspension)

Indications

• Treatment of threadworms
• Treatment of whipworms
• Treatment of roundworms
• Treatment of hookworms

Pharmacology

• Synthetic broad-spectrum anthelmintic
• Active against most nematodes and some other worms
• Inhibits formation of worms' microtubules
• Causes worms' glucose depletion
• 2-10% oral absorption from gastrointestinal tract
• Peak plasma concentration within 30 minutes to 7 hours
• Highly bound to plasma protein
• Elimination half-life of 2.8 to 9 hours

Dosage & Administration

• Adult and Child over 2 years
• Threadworms: 100 mg or 1 teaspoonful - Single dose
• Whipworms, Roundworms, Hookworms: 100 mg or 1 teaspoonful - Twice daily for 3 days
• Second dose may be needed after 2 weeks if reinfection occurs

Interaction

• Preliminary evidence of cimetidine inhibition of Panamox metabolism
• Resulting in increase in plasma concentration

Contraindications

• Known hypersensitivity to Mebendazole or any component of the formulation

Side Effects

• Gastrointestinal: Transient symptoms of abdominal pain and diarrhea
• Hypersensitivity: Rash, urticaria, angioedema
• Central Nervous System: Rare cases of convulsions
• Haematologic: Neutropenia and agranulocytosis

Pregnancy & Lactation

• Not recommended in pregnant women
• Unknown excretion in human milk
• Caution in administration to nursing mothers

Precautions & Warnings

• Periodic assessment of organ system functions during prolonged therapy
• Potential risk to the foetus in women taking Panamox during pregnancy
• Cleanliness is important to prevent reinfection and transmission of the infection

Use in Special Populations

• Not extensively studied in children under two years
• Consider relative benefit/risk in treatment of children under two years

Overdose Effects

• Gastrointestinal complaints lasting up to a few hours in case of accidental overdosage
• Vomiting and purging should be induced

Therapeutic Class

• Anthelmintic

Storage Conditions

• Store in a cool and dry place below 25°C
• Protected from light
• Keep out of the reach of children

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