Delentin 50 mg/ml (Oral Suspension)

Intestinal worm infections

Pinworm infection treatment indicator

• Delentin is specifically indicated for treatment of infestations caused by Ascaris lumbricoides, Enterobius vermicularis, Ancylostoma duodenale/Necator americanus and Trichostrongylus.

Self-treatment usage

• This medication may be used to self-treat pinworm infections.

Minimum age restrictions

• Do not use this medication in children younger than 2 years unless directed by the doctor.

Pharmacological action

• Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, causing sudden contraction, followed by paralysis, of the helminths.

Mode of action effect

• The result of causing the worm to 'lose its grip' on the intestinal wall and be passed out of the system by natural process.

Host absorption impact

• Since Pyrantel is poorly absorbed by the host's intestine, the host is unaffected by the small dosage of medication used.

Potential adverse effect

• Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load.

Adverse effect manifestation

• This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once.

Passing of worms

• Worms usually pass in normal stool or with diarrhea, straining, and occasional vomiting.

Dosage type

• Oral

Administration flexibility

• Pyrantel Pamoate is given orally at anytime without regard to ingestion of food or beverages.

Recommended single dose

• A single dose of 11 mg/kg body weight, to a maximum of 1 gm, should be given to treat infestations caused by the parasites mentioned above.

Repeat dosage suggestion

• In the case of Pinworm, it is often wise to repeat the dose after an interval of 2 weeks.

Contraindication

• Known hypersensitivity to pyrantel or any ingredient in the formulation.

Common side effects

• When given in large dosage, Delentin may cause gastrointestinal upset such as anorexia, nausea, vomiting and diarrhoea.

Rare side effects occurrence

• Other side effects that may occur in rare occasions are headache, dizziness and rash.

Pregnancy recommendation

• Since Pyrantel Pamoate has not been studied in pregnant women, use of Pyrantel Pamoate in such patients is normally contraindicated.

Age recommendation for medication usage

• Pyrantel Pamoate is not recommended for children below 1 year of age.

Medication combination warning

• Since Delentin and Piperazine appear to be mutually antagonistic, Delentin should not be given together with Piperazine.

Child safety indication

• Delentin should be kept out of the reach of children.

Pediatric usage caution

• Safety and efficacy not established in children <2 years of age; use in this age group only when potential benefits justify possible risks.

Hepatic impairment caution

• Use with caution in patients with preexisting liver dysfunction.

Therapeutic class

• Anthelmintic

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