Napa 250 mg (Suppository)

Unit Price: ৳ 5.00 (4 x 5: ৳ 100.00)

Medicine Details

Category Details
Generic Paracetamol
Company Beximco pharmaceuticals ltd
Also available as
Napa 125 mg suppository Napa 500 mg suppository

Indications

  • Fever
  • Common cold and influenza
  • Headache
  • Toothache
  • Earache
  • Bodyache
  • Myalgia
  • Neuralgia
  • Dysmenorrhoea
  • Sprains
  • Colic pain
  • Back pain
  • Post-operative pain
  • Postpartum pain
  • Inflammatory pain
  • Post vaccination pain in children
  • Rheumatic and osteoarthritic pain
  • Stiffness of joints

Pharmacology

  • Analgesic properties
  • Antipyretic properties
  • Weak anti-inflammatory activity
  • Action in the CNS
  • Inhibition of cyclooxygenase (COX-1, COX-2, COX-3) enzymes
  • Increase in pain threshold
  • Prostaglandin synthesis inhibition
  • Para-aminophenol derivative

Dosage & Administration

  • Tablet for adults
  • Tablet for children (6-12 years)
  • Extended release tablet for adults and children over 12 years
  • Syrup/suspension for children under 3 months
  • Syrup/suspension for 3 months to below 1 year
  • Syrup/suspension for 1-5 years
  • Syrup/suspension for 6-12 years
  • Syrup/suspension for adults
  • Suppository for children (3-12 months)
  • Suppository for children (1-5 years)
  • Suppository for children (6-12 years)
  • Suppository for adults and children over 12 years
  • Pediatric drop for children up to 3 months
  • Pediatric drop for 4 to 11 months
  • Pediatric drop for 7 to 12 years
  • Paracetamol tablet with actizorb technology for adults and children (aged 12 years and over)

Interaction

  • Diminished ability to metabolize large doses with barbiturates
  • Diminished ability to metabolize large doses with tricyclic antidepressants
  • Diminished ability to metabolize large doses with alcohol
  • Increased hepatotoxicity of overdosage with alcohol
  • Chronic ingestion effects of anticonvulsants
  • Chronic ingestion effects of oral steroid contraceptives

Contraindications

  • Known hypersensitivity to Paracetamol

Side Effects

  • Mild side effects
  • Haematological reactions including thrombocytopenia
  • Haematological reactions including leucopenia
  • Haematological reactions including pancytopenia
  • Haematological reactions including neutropenia
  • Haematological reactions including agranulocytosis
  • Pancreatitis
  • Skin rashes
  • Other allergic reactions

Pregnancy & Lactation

  • Epidemiological studies show no ill effects in human pregnancy
  • Advice to follow doctor's guidance during pregnancy
  • Excretion in breast milk

Precautions & Warnings

  • Care advised for severe renal impairment
  • Care advised for severe hepatic impairment
  • Hazard of overdose is greater in non-cirrhotic alcoholic liver disease
  • Advice not to exceed the stated dose
  • Advice not to take other Napa-containing products concurrently

Overdose Effects

  • Possible liver damage in adults with 10 g or more intake
  • Liver damage with 5 g or more intake under certain risk factors
  • Symptoms of overdose in the first 24 hours
  • Liver damage becoming apparent 12 to 48 hours after ingestion
  • Abnormalities of glucose metabolism
  • Metabolic acidosis
  • Hepatic failure leading to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, and death
  • Acute renal failure with acute tubular necrosis
  • Immediate treatment essential
  • Treatment with activated charcoal within 1 hour of ingestion
  • Measurement of plasma Napa concentration at 4 hours or later after ingestion
  • Treatment with N-acetylcysteine within 24 hours after ingestion
  • Maximum protective effect within 8 hours post-ingestion
  • Intravenous N-acetylcysteine for serious hepatic dysfunction

Therapeutic Class

  • Non-opioid analgesics

Storage Conditions

  • Keep in dry place
  • Keep away from light
  • Keep away from heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C8H9NO2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-860-paracetamol-chemical-structure-JLKHDuG7hxR2MserFZ27.svg

Common Questions about Napa 250 mg Suppository

  • Action by obstructing the release of pain and fever chemical messengers
  • Uses for post immunization pyrexia, menstrual cramps, and fever
  • Possible side effects including allergic reaction, gastric ulcers, fatigue, anemia, nausea, and vomiting
  • Instructions for storage and disposal
  • Recommendation to take with food or milk
  • Duration of use until complete eradication of the disease
  • Absence of food or drink restrictions
  • No need to take more than recommended doses
  • Consultation required before taking with other medications
  • Non-classification as NSAID drug

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