5-Fluril 25 mg/ml (IV Injection or Infusion)

250 mg vial: ৳ 55.00

Medicine Details

Category Details
Generic Fluorouracil
Company Techno drugs ltd

Indications

  • Carcinoma of the colon or rectum
  • Carcinoma of the stomach and exocrine pancreas
  • Carcinoma of the liver
  • Carcinoma of the breast
  • Carcinoma of the bladder
  • Carcinoma of the lung
  • Epithelial ovarian carcinoma
  • Cervical carcinoma

Pharmacology

Fluorouracil is converted into the active 5-fluorodeoxyuridine monophosphate (FdUMP) by a variety of different metabolic pathways. It inhibits the enzyme thymidylate kinase, reduces DNA formation, and is incorporated into RNA resulting in fluorination of RNA.

Dosage & Administration

  • Dosage of 12-13.5 mg/Kg (500 mg/m2) daily for 5 days repeated at 4-weekly intervals
  • Intravenous administration over 2-3 hr on 5 successive days
  • Intra-arterial infusion options
  • Combination with radiation or other anticancer drugs

Interaction

Pre-treatment with cimetidine may increase plasma concentrations of 5-Fluril.

Contraindications

Contraindicated in severely debilitated patients, those with bone marrow suppression, pregnant or breastfeeding women, and non-malignant illnesses.

Side Effects

  • Potentially life-threatening cardiac effects
  • Hematological effects
  • Neurological effects
  • Allergic reactions
  • Hand-foot syndrome
  • Vomiting, diarrhea, or stomach pain
  • Mild to moderate nausea, vomiting or loss of appetite
  • Rash and itching
  • Temporary hair loss
  • Conjunctivitis

Pregnancy & Lactation

Contraindicated throughout pregnancy and breastfeeding due to risk of teratogenesis and inhibition of DNA, RNA, and protein synthesis.

Precautions & Warnings

5-Fluril is highly toxic and therapy should be discontinued promptly when signs of toxicity appear.

Use in Special Populations

  • No dosage recommendations for neonates
  • Safety and effectiveness not established in children
  • Doses adjusted for the elderly

Overdose Effects

No specific antidote to 5-Fluril toxicity; treatment consists of supportive care.

Reconstitution

Special personnel and precautions required for reconstitution; handling should be done with protective equipment and careful disposal of contaminated waste.

Storage Conditions

Vial should be stored in original carton at temperatures not exceeding 25℃, protected from light.

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