Centamol 500 mg+65 mg (Tablet)
Unit Price: ৳ 1.90 (100's pack: ৳ 190.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Paracetamol caffeine |
| Company | Central pharmaceuticals ltd |
Indications
- Headache
- Migraine
- Toothache
- Neuralgia
- Feverishness
- Period pain
- Sore throat
- Backache
- Help to reduce the temperature
- Aches and pain of colds and flu
Pharmacology
- Combination of Paracetamol and Caffeine
- Analgesic and antipyretic properties
- Weak anti-inflammatory activity
- Increases solubility and transmembrane permeation of Paracetamol
- Increases pain threshold and tolerance of pain
- Raises vessel tone in the brain
Dosage & Administration
- Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily
- Child dose: Not recommended for children below 12 years
Interaction
- May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine)
- May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
- Accelerated absorption with metoclopramide and domperidone
- May increase serum levels with probenecid
- May increase serum levels of chloramphenicol
- May reduce absorption with colestyramine within 1 hr of admin
- May cause severe hypothermia with phenothiazine
Contraindications
- Severe renal function impairment and hepatic disease
- Known hypersensitivity to paracetamol or caffeine
Side Effects
- Mild side effects
- Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
- Pancreatitis, skin rashes, and other allergic reactions
Pregnancy & Lactation
Consultation required during pregnancy, safe while breastfeeding
Precautions & Warnings
- Cautious use in patients with hepatic or renal failure
- Avoid prolonged use without consulting a physician
Overdose Effects
- Symptoms of Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia, and abdominal pain
- Liver damage may become apparent 12 to 40 hours after ingestion
- Abnormalities of glucose metabolism and metabolic acidosis may occur
Therapeutic Class
Non opioid analgesics
Storage Conditions
Store in a cool and dry place, protect from light and moisture. Keep out of reach of children