Centamol 500 mg+65 mg (Tablet)

Unit Price: ৳ 1.90 (100's pack: ৳ 190.00)

Medicine Details

Category Details
Generic Paracetamol caffeine
Company Central pharmaceuticals ltd

Indications

  • Headache
  • Migraine
  • Toothache
  • Neuralgia
  • Feverishness
  • Period pain
  • Sore throat
  • Backache
  • Help to reduce the temperature
  • Aches and pain of colds and flu

Pharmacology

  • Combination of Paracetamol and Caffeine
  • Analgesic and antipyretic properties
  • Weak anti-inflammatory activity
  • Increases solubility and transmembrane permeation of Paracetamol
  • Increases pain threshold and tolerance of pain
  • Raises vessel tone in the brain

Dosage & Administration

  • Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily
  • Child dose: Not recommended for children below 12 years

Interaction

  • May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine)
  • May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
  • Accelerated absorption with metoclopramide and domperidone
  • May increase serum levels with probenecid
  • May increase serum levels of chloramphenicol
  • May reduce absorption with colestyramine within 1 hr of admin
  • May cause severe hypothermia with phenothiazine

Contraindications

  • Severe renal function impairment and hepatic disease
  • Known hypersensitivity to paracetamol or caffeine

Side Effects

  • Mild side effects
  • Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
  • Pancreatitis, skin rashes, and other allergic reactions

Pregnancy & Lactation

Consultation required during pregnancy, safe while breastfeeding

Precautions & Warnings

  • Cautious use in patients with hepatic or renal failure
  • Avoid prolonged use without consulting a physician

Overdose Effects

  • Symptoms of Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia, and abdominal pain
  • Liver damage may become apparent 12 to 40 hours after ingestion
  • Abnormalities of glucose metabolism and metabolic acidosis may occur

Therapeutic Class

Non opioid analgesics

Storage Conditions

Store in a cool and dry place, protect from light and moisture. Keep out of reach of children

Related Brands