Dual 500 mg+65 mg (Tablet)

Unit Price: ৳ 2.50 (10 x 10: ৳ 250.00)
Strip Price: ৳ 25.00

Medicine Details

Category Details
Generic Paracetamol caffeine
Company Medicon pharmaceuticals ltd

Indications

  • Headache
  • Migraine
  • Toothache
  • Neuralgia
  • Feverishness
  • Period pain
  • Sore throat
  • Backache
  • Help to reduce the temperature
  • Aches and pain of colds and flu

Pharmacology

  • Combination of Paracetamol and Caffeine
  • Analgesic and antipyretic properties of Paracetamol
  • Weak anti-inflammatory activity of Paracetamol
  • Theophylline-like xanthine derivative properties of Caffeine
  • Increased solubility and transmembrane permeation of Paracetamol by Caffeine
  • Increased pain threshold and tolerance of pain by Caffeine
  • Intrinsic power to raise vessel tone in the brain by Caffeine

Dosage & Administration

  • Adult dose: 1-2 tablets every 4-6 hours
  • Maximum adult dose: 8 tablets daily
  • Not recommended for children below 12 years

Interaction

  • May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine)
  • May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
  • Accelerated absorption with metoclopramide and domperidone
  • May increase serum levels with probenecid
  • May increase serum levels of chloramphenicol
  • May reduce absorption with colestyramine within 1 hr of admin
  • May cause severe hypothermia with phenothiazine

Contraindications

  • Severe renal function impairment
  • Hepatic disease (Viral Hepatitis)
  • Known hypersensitivity to Paracetamol or Caffeine

Side Effects

  • Mild side effects of Paracetamol
  • Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
  • Pancreatitis
  • Skin rashes
  • Other allergic reactions

Pregnancy & Lactation

  • Consultation required for pregnant mothers
  • Can be taken whilst breastfeeding

Precautions & Warnings

  • Cautious use in patients with hepatic or renal failure
  • Cautious use in patients taking other hepatotoxic medication
  • Avoid prolonged use without consulting a physician

Overdose Effects

  • Symptoms of Paracetamol overdose in the first 24 hours
  • Liver damage may become apparent 12 to 40 hours after ingestion
  • Abnormalities of glucose metabolism
  • Metabolic acidosis

Therapeutic Class

  • Non opioid analgesics

Storage Conditions

  • Cool and dry place
  • Protect from light and moisture
  • Keep out of the reach of children

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