Fibi Plus 500 mg+65 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Paracetamol caffeine |
| Company | Mst pharma |
Indications
- Headache
- Migraine
- Toothache
- Neuralgia
- Feverishness
- Period pain
- Sore throat
- Backache
- Help to reduce the temperature
- Aches and pain of colds and flu
Pharmacology
Combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine increases solubility and transmembrane permeation of Paracetamol. It also increases pain threshold, tolerance of pain, and vessel tone in the brain.
Dosage & Administration
- Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.
- Child dose: Not recommended for children below 12 years.
Interaction
- May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine)
- May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
- Accelerated absorption with metoclopramide and domperidone
- May increase serum levels with probenecid
- May increase serum levels of chloramphenicol
- May reduce absorption with colestyramine within 1 hr of admin
- May cause severe hypothermia with phenothiazine
Contraindications
Severe renal function impairment, hepatic disease (Viral Hepatitis), known hypersensitivity to paracetamol or caffeine.
Side Effects
- Mild side effects of paracetamol
- Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
- Pancreatitis, skin rashes, and other allergic reactions
Pregnancy & Lactation
Consult with doctors before taking Paracetamol & Caffeine. Can be taken whilst breastfeeding.
Precautions & Warnings
- Cautious use in patients with hepatic or renal failure
- Cautious use in patients taking other hepatotoxic medication
- Avoid prolonged use without consulting a physician
Overdose Effects
Symptoms of Paracetamol overdose include pallor, nausea, vomiting, anorexia, abdominal pain, liver damage, abnormalities of glucose metabolism, and metabolic acidosis.
Therapeutic Class
Non-opioid analgesics
Storage Conditions
Store in a cool and dry place, protect from light and moisture. Keep all medicines out of the reach of children.