PAC 500 mg+65 mg (Tablet)

Unit Price: ৳ 2.50 (20 x 10: ৳ 500.00)
Strip Price: ৳ 25.00

Medicine Details

Indications

  • Headache
  • Migraine
  • Toothache
  • Neuralgia
  • Feverishness
  • Period pain
  • Sore throat
  • Backache
  • Help to reduce the temperature
  • Aches and pain of colds and flu

Pharmacology

  • Combination of Paracetamol and Caffeine
  • Paracetamol has analgesic and antipyretic properties
  • Caffeine increases the solubility and transmembrane permeation of Paracetamol
  • Caffeine increases the pain threshold and tolerance of pain
  • Caffeine raises vessel tone in the brain

Dosage & Administration

  • Adult dose: 1-2 tablets every 4-6 hours
  • Maximum adult dose: 8 tablets daily
  • Not recommended for children below 12 years

Interaction

  • May reduce serum levels with anticonvulsants
  • May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
  • Accelerated absorption with metoclopramide and domperidone
  • May increase serum levels with probenecid
  • May increase serum levels of chloramphenicol
  • May reduce absorption with colestyramine within 1 hr of admin
  • May cause severe hypothermia with phenothiazine

Contraindications

  • Severe renal function impairment
  • Hepatic disease (Viral Hepatitis)
  • Known hypersensitivity to paracetamol or caffeine

Side Effects

  • Mild side effects of paracetamol
  • Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
  • Pancreatitis
  • Skin rashes
  • Other allergic reactions

Pregnancy & Lactation

  • Consultation required during pregnancy
  • Can be taken while breastfeeding

Precautions & Warnings

  • Cautious use in patients with hepatic or renal failure
  • Cautious use in patients taking other hepatotoxic medication
  • Avoid prolonged use without consulting a physician

Overdose Effects

  • Symptoms of Paracetamol overdose in the first 24 hours
  • Pallor
  • Nausea
  • Vomiting
  • Anorexia
  • Abdominal pain
  • Liver damage may become apparent 12 to 40 hours after ingestion
  • Abnormalities of glucose metabolism
  • Metabolic acidosis

Therapeutic Class

  • Non opioid analgesics

Storage Conditions

  • Cool and dry place
  • Protect from light and moisture
  • Keep out of the reach of children

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