PAC 500 mg+65 mg (Tablet)
Unit Price: ৳ 2.50 (20 x 10: ৳ 500.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paracetamol caffeine |
| Company | Ibn sina pharmaceuticals ltd |
Indications
- Headache
- Migraine
- Toothache
- Neuralgia
- Feverishness
- Period pain
- Sore throat
- Backache
- Help to reduce the temperature
- Aches and pain of colds and flu
Pharmacology
- Combination of Paracetamol and Caffeine
- Paracetamol has analgesic and antipyretic properties
- Caffeine increases the solubility and transmembrane permeation of Paracetamol
- Caffeine increases the pain threshold and tolerance of pain
- Caffeine raises vessel tone in the brain
Dosage & Administration
- Adult dose: 1-2 tablets every 4-6 hours
- Maximum adult dose: 8 tablets daily
- Not recommended for children below 12 years
Interaction
- May reduce serum levels with anticonvulsants
- May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
- Accelerated absorption with metoclopramide and domperidone
- May increase serum levels with probenecid
- May increase serum levels of chloramphenicol
- May reduce absorption with colestyramine within 1 hr of admin
- May cause severe hypothermia with phenothiazine
Contraindications
- Severe renal function impairment
- Hepatic disease (Viral Hepatitis)
- Known hypersensitivity to paracetamol or caffeine
Side Effects
- Mild side effects of paracetamol
- Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
- Pancreatitis
- Skin rashes
- Other allergic reactions
Pregnancy & Lactation
- Consultation required during pregnancy
- Can be taken while breastfeeding
Precautions & Warnings
- Cautious use in patients with hepatic or renal failure
- Cautious use in patients taking other hepatotoxic medication
- Avoid prolonged use without consulting a physician
Overdose Effects
- Symptoms of Paracetamol overdose in the first 24 hours
- Pallor
- Nausea
- Vomiting
- Anorexia
- Abdominal pain
- Liver damage may become apparent 12 to 40 hours after ingestion
- Abnormalities of glucose metabolism
- Metabolic acidosis
Therapeutic Class
- Non opioid analgesics
Storage Conditions
- Cool and dry place
- Protect from light and moisture
- Keep out of the reach of children