Caface 500 mg+65 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Paracetamol caffeine |
| Company | Leon pharmaceuticals ltd |
Indications
- Headache
- Migraine
- Toothache
- Neuralgia
- Feverishness
- Period pain
- Sore throat
- Backache
- Help to reduce the temperature
- Aches and pain of colds and flu
Pharmacology
Combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.
Dosage & Administration
- Adult dose: 1-2 tablets every 4-6 hours
- Maximum dose: 8 tablets daily
- Child dose: Not recommended for children below 12 years
Interaction
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.
Contraindications
Severe renal function impairment, hepatic disease (Viral Hepatitis), known hypersensitivity to paracetamol or caffeine
Side Effects
- Mild side effects
- Haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
- Pancreatitis
- Skin rashes
- Allergic reactions
Pregnancy & Lactation
Consult with doctors before taking Paracetamol & Caffeine during pregnancy. Can be taken whilst breastfeeding
Precautions & Warnings
Given cautiously in patients with hepatic or renal failure, in patients taking other hepatotoxic medication. Prolonged use of the drug without consulting a physician should be avoided
Overdose Effects
Symptoms of Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 40 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur
Therapeutic Class
Non opioid analgesics
Storage Conditions
Store in a cool and dry place, protect from light and moisture. Keep all medicines out of the reach of the children