Doloran 100 mg (Suppository)

Unit Price: ৳ 20.00 (2 x 5: ৳ 200.00)

Medicine Details

Product Title

  • Doloran

Category

  • Pain Relief Medication
  • Opioid Analgesic

Indications

  • Treatment of moderate to severe painful conditions
  • Postoperative pain
  • Colic and spastic pain
  • Cancer pain
  • Joint pain
  • Neck and back pain
  • Pain associated with osteoporosis

Pharmacology

  • Centrally acting synthetic analgesic compound
  • Inhibition of reuptake of neurotransmitters- serotonin and noradrenaline
  • Modifies the transmission of pain impulses
  • Stimulation of mu-opioid receptors
  • Modulation of central monoaminergic inhibitory pathways

Dosage & Administration

  • Usual doses of 50 to 100 mg every four to six hours
  • Initial dose of 100 mg for acute pain
  • Initial dose of 50 mg for chronic painful conditions
  • Subsequent doses of 50 to 100 mg administered 4-6 hourly
  • Total daily dosage by mouth should not exceed 400 mg
  • One sustained release capsule or tablet every 12 hours
  • 50-100 mg injection every 4 to 6 hours
  • Tramadol suppository administered rectally, with usual dose of 100 mg every 6 hours for adults

Interaction

  • Monoamine oxidase (MAO) inhibitors not recommended for combination with Doloran
  • Concomitant administration of carbamazepine requires adjustment of Doloran dose

Contraindications

  • Hypersensitivity to Tramadol
  • Acute intoxication with alcohol, hypnotics, opioids or psychotropic drugs

Side Effects

  • Common side effects: dizziness/vertigo, nausea, constipation, headache, somnolence, vomiting, pruritus, CNS stimulation, asthenia, sweating, dyspepsia, dry mouth, diarrhoea
  • Less common side effects: malaise, allergic reaction, weight loss, vasodilatation, palpitations, abdominal pain, anorexia, flatulence, GI bleeding, hepatitis, stomatitis

Pregnancy & Lactation

  • Safe use in pregnancy not established
  • Crosses the placenta
  • Use during pregnancy only if potential benefit justifies risk to the fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Cautious administration in patients at risk for respiratory depression
  • Not recommended for patients dependent on opioids
  • Caution with concomitant CNS depressants
  • Caution in patients taking MAO inhibitors
  • Use with caution in patients with increased intracranial pressure or head injury and acute abdominal conditions

Use in Special Populations

  • Dose of 1-2 mg/kg body weight in children from the age of 1 year
  • Suppository not for administration in children and adolescents below the age of 14 years
  • Doloran 100 mg SR Capsules not studied in children; safety and efficacy not established

Therapeutic Class

  • Opioid analgesics

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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