Syndol 100 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 25.00 (1 x 5: ৳ 125.00)

Medicine Details

Category Details
Generic Tramadol hydrochloride
Company Healthcare pharmaceuticals ltd
Also available as
Syndol 50 mg capsule

Indications

  • Moderate to severe painful conditions
  • Postoperative pain
  • Colic and spastic pain
  • Cancer pain
  • Joint pain
  • Neck and back pain
  • Pain associated with osteoporosis

Pharmacology

  • Centrally acting synthetic analgesic compound
  • Inhibits reuptake of neurotransmitters - serotonin and noradrenaline
  • Modifies transmission of pain impulses
  • Activates descending serotonergic pathways
  • Activates noradrenergic pathways involved in analgesia

Dosage & Administration

  • Usual doses of 50 to 100 mg every four to six hours
  • Initial dose of 100 mg for acute pain
  • Capsule, tablet, sustained release capsule, injection, suppository administration
  • Total daily dosage by mouth should not exceed 400 mg

Interaction

  • No major drug interactions
  • Monoamine oxidase (MAO) inhibitors not recommended for combination
  • Concomitant administration of carbamazepine requires dose adjustment

Contraindications

  • Hypersensitivity to the drug
  • Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs

Side Effects

  • Dizziness/vertigo
  • Nausea
  • Constipation
  • Headache
  • Somnolence
  • Vomiting
  • Pruritus
  • CNS stimulation
  • Asthenia
  • Sweating
  • Dyspepsia
  • Dry mouth
  • Diarrhoea
  • Malaise
  • Allergic reaction
  • Weight loss
  • Vasodilatation
  • Palpitations
  • Abdominal pain
  • Anorexia
  • Flatulence
  • GI bleeding
  • Hepatitis
  • Stomatitis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Crosses the placenta
  • Use during pregnancy if benefit justifies risk to the fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Respiratory depression risk
  • Not recommended for opioid-dependent patients
  • Caution with concomitant CNS depressants
  • Caution with concomitant MAO inhibitors
  • Caution in patients with increased intracranial pressure or head injury
  • Caution in patients with acute abdominal conditions

Use in Special Populations

  • Children (age 1 year and above) administration
  • Suppository not recommended for children below 14 years
  • Safety and efficacy not established for Syndol 100 mg SR Capsules in children

Therapeutic Class

  • Opioid analgesics

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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