Syndol 100 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 25.00 (1 x 5: ৳ 125.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tramadol hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Moderate to severe painful conditions
- Postoperative pain
- Colic and spastic pain
- Cancer pain
- Joint pain
- Neck and back pain
- Pain associated with osteoporosis
Pharmacology
- Centrally acting synthetic analgesic compound
- Inhibits reuptake of neurotransmitters - serotonin and noradrenaline
- Modifies transmission of pain impulses
- Activates descending serotonergic pathways
- Activates noradrenergic pathways involved in analgesia
Dosage & Administration
- Usual doses of 50 to 100 mg every four to six hours
- Initial dose of 100 mg for acute pain
- Capsule, tablet, sustained release capsule, injection, suppository administration
- Total daily dosage by mouth should not exceed 400 mg
Interaction
- No major drug interactions
- Monoamine oxidase (MAO) inhibitors not recommended for combination
- Concomitant administration of carbamazepine requires dose adjustment
Contraindications
- Hypersensitivity to the drug
- Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs
Side Effects
- Dizziness/vertigo
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
- Pruritus
- CNS stimulation
- Asthenia
- Sweating
- Dyspepsia
- Dry mouth
- Diarrhoea
- Malaise
- Allergic reaction
- Weight loss
- Vasodilatation
- Palpitations
- Abdominal pain
- Anorexia
- Flatulence
- GI bleeding
- Hepatitis
- Stomatitis
Pregnancy & Lactation
- Safety in pregnancy not established
- Crosses the placenta
- Use during pregnancy if benefit justifies risk to the fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Respiratory depression risk
- Not recommended for opioid-dependent patients
- Caution with concomitant CNS depressants
- Caution with concomitant MAO inhibitors
- Caution in patients with increased intracranial pressure or head injury
- Caution in patients with acute abdominal conditions
Use in Special Populations
- Children (age 1 year and above) administration
- Suppository not recommended for children below 14 years
- Safety and efficacy not established for Syndol 100 mg SR Capsules in children
Therapeutic Class
- Opioid analgesics
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children