Ultranax Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 18.00 (5 x 10: ৳ 900.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Ad din pharmaceuticals ltd

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Mechanism of action of Naproxen to inhibit prostaglandin synthesis
  • Mechanism of action of Esomeprazole as a proton pump inhibitor to suppress gastric acid secretion

Dosage

  • Use lowest effective dose for the shortest duration consistent with individual patient treatment goals
  • Adult dosage: One tablet twice daily of either 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole
  • Juvenile Idiopathic Arthritis dosage: Varies based on patient weight

Administration

  • Tablet to be taken at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of tablet and warfarin may result in an increased risk of a bleeding complication
  • Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • Administration of tablet together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen

Contraindications

  • Known hypersensitivity to any component of this tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • Gastrointestinal adverse events, arterial thrombotic events, oedema, hypertension, cardiac failure
  • Commonly observed adverse events are gastrointestinal in nature
  • Potential reduction in absorption of vitamin B12 due to hypo- or achlorhydria induced by acid-blocking medicines

Pregnancy & Lactation

  • Contraindicated during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • Potential impairment of female fertility with NSAID use

Precautions & Warnings

  • Avoid the combination of Naproxen and NSAIDs including cyclooxygenase-2 selective inhibitors
  • Consideration for patients with risk factors for cardiovascular events
  • Regular surveillance for patients on long-term treatment over a year

Use in Special Populations

  • Dosage adjustment for elderly patients
  • Not recommended in patients with moderate to severe or severe renal impairment
  • Close monitoring for patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms related to Naproxen overdose including lethargy, dizziness, epigastric pain, abdominal discomfort, heartburn, nausea, alterations in liver function
  • Management includes symptomatic and supportive care, emesis, activated charcoal, and osmotic cathartic

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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