Zydol 50 mg (Capsule)

Unit Price: ৳ 7.52 (30's pack: ৳ 225.67)

Medicine Details

Category Details
Generic Tramadol hydrochloride
Company Novo healthcare and pharma ltd
Also available as
Zydol sr 100 mg capsule Zydol 100 mg injection

Indications

  • Treatment of moderate to severe painful conditions
  • Postoperative pain
  • Colic and spastic pain
  • Cancer pain
  • Joint pain
  • Neck and back pain
  • Pain associated with osteoporosis

Pharmacology

  • Centrally acting synthetic analgesic compound
  • Inhibition of reuptake of neurotransmitters- serotonin and noradrenaline
  • Modification of transmission of pain impulses
  • Activation of descending serotonergic pathways
  • Activation of noradrenergic pathways involved in analgesia
  • Stimulation of mu-opioid receptors
  • Modulation of central monoaminergic inhibitory pathways

Dosage & Administration

  • Usual doses of 50 to 100 mg every four to six hours
  • Initial dose of 100 mg for acute pain
  • Initial dose of 50 mg for chronic painful conditions
  • Total daily dosage by mouth should not exceed 400 mg
  • Dosage for sustained release capsule or tablet
  • Dose of 50-100 mg per 4 to 6 hours for injection
  • Dose of 100 mg Tramadol Hydrochloride 6 hourly for suppository

Interaction

  • Monoamine oxidase (MAO) inhibitors not recommended for combination
  • Concomitant administration of carbamazepine causes significant increase in Zydol metabolism

Contraindications

  • Hypersensitivity to the drug
  • Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs

Side Effects

  • Dizziness/vertigo
  • Nausea
  • Constipation
  • Headache
  • Somnolence
  • Vomiting
  • Pruritus
  • CNS stimulation
  • Asthenia
  • Sweating
  • Dyspepsia
  • Dry mouth
  • Diarrhoea
  • Malaise
  • Allergic reaction
  • Weight loss
  • Vasodilatation
  • Palpitations
  • Abdominal pain
  • Anorexia
  • Flatulence
  • GI bleeding
  • Hepatitis
  • Stomatitis

Pregnancy & Lactation

  • Safe use in pregnancy not established
  • Crosses the placenta
  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies the risk to the fetus
  • Not to be administered during breastfeeding

Precautions & Warnings

  • Respiratory depression
  • Cautious administration in patients at risk for respiratory depression
  • Not recommended for patients dependent on opioids
  • Cautious use with concomitant CNS depressants
  • Cautious use in patients with increased intracranial pressure or head injury
  • Cautious use in patients with acute abdominal conditions

Use in Special Populations

  • Dosing in children from the age of 1 year
  • Suppository (100 mg Zydol) not to be administered in children and adolescents below the age of 14 years
  • Zydol 100 mg SR Capsules not studied in children

Therapeutic Class

  • Opioid analgesics

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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