Xtrapel 100 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 20.13 (1 x 5: ৳ 100.65)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tramadol hydrochloride |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Postoperative pain
- Colic and spastic pain
- Cancer pain
- Joint pain
- Neck and back pain
- Pain associated with osteoporosis
Pharmacology
- Centrally acting synthetic analgesic
- Inhibits reuptake of neurotransmitters (serotonin and noradrenaline)
- Modifies transmission of pain impulses
- Stimulation of mu-opioid receptors
- Activation of serotonergic and noradrenergic pathways
Dosage & Administration
- Dosage forms: Capsule, tablet, sustained release capsule/tablet, injection, suppository
- Doses of 50-100 mg every 4-6 hours
- Initial dose of 100 mg for acute pain, 50 mg for chronic painful conditions
- Usual dosing frequency
- Max daily dosage by mouth: 400 mg
- Dosing adjustment for postoperative pain
Interaction
- Interaction with monoamine oxidase (MAO) inhibitors
- Increased metabolism with carbamazepine
Contraindications
- Hypersensitivity to tramadol
- Contraindicated in acute intoxication with certain substances
Side Effects
- Dizziness/vertigo
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
- Pruritus
- CNS stimulation
- Asthenia
- Sweating
- Dyspepsia
- Dry mouth
- Diarrhoea
- Malaise
- Allergic reaction
- Weight loss
- Vasodilatation
- Palpitations
- Abdominal pain
- Anorexia
- Flatulence
- GI bleeding
- Hepatitis
- Stomatitis
Pregnancy & Lactation
- Crosses the placenta
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if benefit justifies risk
- Not recommended during breastfeeding
Precautions & Warnings
- Respiratory depression risk
- Risk in patients dependent on opioids
- Caution with concomitant CNS depressants
- Caution with concomitant MAO inhibitors
- Caution in patients with increased intracranial pressure or head injury
- Caution in patients with acute abdominal conditions
Use in Special Populations
- Dosage for children over 1 year old
- Suppository not recommended for children under 14 years old
- Safety and efficacy not established in children for specific product
Therapeutic Class
- Opioid analgesics
Storage Conditions
- Storage temperature: Below 30°C
- Storage away from light & moisture
- Keep out of the reach of children