Panol-T 325 mg+37.5 mg (Tablet)

Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Paracetamol tramadol hydrochloride
Company Virgo pharmaceuticals ltd

Indications

  • Management of moderate to moderately severe pain in adults
  • Short-term management of acute pain

Pharmacology

  • Paracetamol with analgesic and antipyretic properties
  • Weak anti-inflammatory activity
  • Thought to act primarily in the CNS
  • Increases pain threshold by inhibiting cyclooxygenase (COX-1, COX-2, COX-3) enzymes
  • Tramadol - centrally acting synthetic opioid analgesic
  • Mode of action not completely understood
  • Binding to μ-opioid receptors
  • Inhibition of norepinephrine and serotonin reuptake

Dosage & Administration

  • Recommended dose for moderate to moderately severe pain
  • Recommended dose for short-term (five days or less) management of acute pain
  • Can be administered without regard to food

Contraindications

  • Hypersensitivity to tramadol, paracetamol, or opioids
  • Contraindicated in situations where opioids are contraindicated

Side Effects

  • Asthenia
  • Fatigue
  • Hot flushes
  • Dizziness
  • Headache
  • Tremor
  • Abdominal pain
  • Constipation
  • Diarrhea
  • Dyspepsia
  • Dry mouth
  • Nausea
  • Vomiting
  • Anorexia
  • Anxiety
  • Confusion
  • Euphoria
  • Insomnia
  • Nervousness
  • Somnolence
  • Pruritus
  • Rash
  • Increased sweating

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies potential risk to fetus
  • Not recommended for obstetrical preoperative medication or post-delivery analgesia in nursing mothers

Precautions & Warnings

  • May impair mental or physical abilities
  • Should not be taken with alcohol
  • Should not be taken in combination with other tramadol or paracetamol-containing products
  • Use with caution when taking tranquilizers, hypnotics or other opiate containing analgesics

Use in Special Populations

  • Safety and effectiveness not studied in the pediatric population
  • Dose selection for elderly patients should be cautious
  • Not studied in patients with impaired renal function
  • In patients with creatinine clearances of less than 30 ml/min, dosing interval should be increased
  • Not studied in patients with impaired hepatic function
  • Not recommended for use in patients with hepatic impairment

Therapeutic Class

  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store in a cool and dry place
  • Do not freeze
  • Keep out of the reach of children

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