D-Fen 1.5 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pizotifen |
| Company | Drug international ltd |
| Also available as |
Indications
- Prophylactic treatment of vascular headache of migraine type
- Classical migraine
- Common migraine
- Cluster headache
Description
- Tricyclic compound
- Antagonizes serotonin receptor
- Antihistamine properties
- Antibradykinin properties
- Weak anticholinergic properties
- Appetite-stimulating properties
Pharmacology
- Inhibits peripheral actions of serotonin and histamine
- Increases membrane permeability of cranial vessels
- Alters pain thresholds in migraines
- Blocks 5-HT receptors
- Attenuates serotonin signaling causing cranial vasoconstriction
- Inhibits peripheral actions of bradykinin
- Inhibits serotonin reuptake by blood platelets
- Decreases passive distension of extracranial arteries
Dosage & Administration
- Adults: Usually 1.5 mg daily
- May be taken as a single dose at night or in three divided doses
- Dosage should be adjusted to individual patient requirements up to a maximum of 4.5 mg daily
- Children (aged over 2 years): Up to 1.5 mg daily
- Usually as a divided dose
Interaction
- Enhances central effects of sedatives, hypnotics, antihistamines, and alcohol
- Antagonizes hypotensive effect of adrenergic neurone blockers
Contraindications
- Known hypersensitivity to any of its ingredients
Side Effects
- Appetite stimulating effect
- Increase in body weight
- Drowsiness
Pregnancy & Lactation
- Limited information on use in pregnancy
- No ill effects reported
- Pizotifen should only be given during pregnancy if the potential benefit justifies potential risk to the fetus
- Safety during lactation not established
- Mothers should avoid taking it when breastfeeding
Precautions & Warnings
- Consider urinary retention and renal impairment
- Drowsiness may affect driving and operation of machinery
- Enhances the action of alcohol
Therapeutic Class
- Anti-histamine Preparations
- Other drugs for migraine
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children