Flurium 5 mg (Tablet)
Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis of classic migraine with aura
- Prophylaxis of common migraine without aura
- Symptomatic treatment of vestibular vertigo
- Prophylaxis of peripheral vascular disease (PVD)
- Treatment of motion sickness
- Treatment of refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is a difluorinated derivative of cinnarizine
- Selective calcium channel antagonist
- Prevents cellular calcium overload
- Has antihistaminic and sedative properties
- Binds at an affinity of 99% to plasma protein
Dosage & Administration
- Starting dose: 10 mg at night in patients less than 65 years of age
- Starting dose: 5 mg daily in patients older than 65 years
- Maintenance treatment: Decrease to 5 days treatment with two successive medicine free days every week
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults, 5 mg daily for children (>40 kg)
- Epileptic seizure: 15-20 mg daily in adults, 5-10 mg daily for children as an add-on therapy
Interaction
Galactorrhoea reported in few women on oral contraceptives within the first two months of Flurium treatment. Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Flurium by increasing its metabolism, requiring an increase in dosage.
Contraindications
- Hypersensitivity to Flunarizine
- History of depressive illness
- Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Adverse experiences during chronic treatment: depression, extrapyramidal symptoms, heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache, skin rash
Pregnancy & Lactation
Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness which is aggravated by simultaneous intake of alcohol or other central nervous system depressants
- Caution against driving motor vehicles or performing other potentially hazardous tasks
- Not suited for aborting a migraine attack
- May reveal Parkinsonism, especially in predisposed patients
- Use with caution in elderly patients
Therapeutic Class
Miscellaneous prophylactic migraine preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.