Minium 5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Prophylaxis of classic (with aura) or common (without aura) migraine
- Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
- Peripheral Vascular Disease (PVD)
- Motion sickness
- Refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
Flunarizine is a difluorinated derivative of cinnarizine, a selective calcium channel antagonist. It reduces excessive transmembrane influx of calcium to prevent cellular calcium overload without interfering with normal cellular calcium homeostasis. It also has antihistaminic and sedative properties and binds at an affinity of 99% to plasma protein.
Dosage & Administration
- Migraine Prophylaxis: Starting Dose - 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If intolerable symptoms occur, administration should be discontinued. Maintenance Treatment: If a patient responds satisfactorily, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine-free days every week. Peripheral Vascular Disease: 10 mg twice daily, up to 30 mg per day if required. Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg). Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.
- Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).
- Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
Interaction
Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Minium treatment. Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Minium by increasing its metabolism, necessitating a possible increase in Minium dosage.
Contraindications
- Hypersensitivity to Flunarizine
- History of depressive illness
- Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Depression
- Extrapyramidal symptoms (bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor)
- Heartburn
- Nausea
- Gastralgia
- Insomnia
- Anxiety
- Galactorrhoea
- Dry mouth
- Muscle ache
- Skin rash
Pregnancy & Lactation
Safety in pregnancy and lactation has not been established.
Precautions & Warnings
- May lead to drowsiness, aggravated by simultaneous intake of alcohol or other central nervous system depressants
- Patients cautioned against driving motor vehicles or performing other potentially hazardous tasks
- Not suited for aborting a migraine attack
- Possible occurrence of an attack is not a reason to increase the dose
- May give rise to extrapyramidal and depressive symptoms, revealing Parkinsonism, especially in predisposed patients such as the elderly
Therapeutic Class
Miscellaneous prophylactic migraine preparations
Storage Conditions
Keep below 30°C, away from light & moisture. Keep out of the reach of children.