Minium 10 mg (Tablet)
Unit Price: ৳ 5.02 (5 x 10: ৳ 251.00)
Strip Price: ৳ 50.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Prophylaxis of classic (with aura) or common (without aura) migraine
- Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
- Peripheral Vascular Disease (PVD)
- Motion sickness
- Refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is the difluorinated derivative of cinnarizine
- Selective calcium channel antagonist
- Reduces excessive transmembrane influx of calcium
- Prevents cellular calcium overload
- Antihistaminic and sedative properties
Dosage & Administration
- Migraine Prophylaxis: Starting Dose 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years
- Migraine Prophylaxis: Maintenance treatment requires a decrease to 5 days treatment at the same daily dose with two successive medicine-free days every week
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (>40 kg)
- Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
Interaction
Galactorrhoea reported in few women on oral contraceptives within the first two months of Minium treatment. Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Minium by increasing its metabolism, requiring an increase in dosage of Minium
Contraindications
Hypersensitivity to Flunarizine. Contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Depression, particularly in female patients with a history of depressive illness
- Extrapyramidal symptoms, especially in elderly patients
- Heartburn
- Nausea
- Gastralgia
- Insomnia
- Anxiety
- Galactorrhoea
- Dry mouth
- Muscle ache
- Skin rash
Pregnancy & Lactation
Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness, aggravated by simultaneous intake of alcohol or other central nervous system depressants
- Patients cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents
- Not suited for aborting a migraine attack
- May give rise to extrapyramidal and depressive symptoms, revealing Parkinsonism, especially in predisposed patients such as the elderly
Therapeutic Class
Miscellaneous prophylactic migraine preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children