Norium 5 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Flunarizine
Company Eskayef pharmaceuticals ltd
Also available as

Indications

  • Prophylaxis of classic (with aura) or common (without aura) migraine
  • Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
  • Peripheral Vascular Disease (PVD)
  • Motion sickness
  • Refractory epilepsy resistant to conventional antiepileptic therapy

Pharmacology

  • Flunarizine is the difluorinated derivative of cinnarizine
  • Selective calcium channel antagonist
  • Prevents cellular calcium overload
  • Has antihistaminic and sedative properties
  • Binds at an affinity of 99% to plasma protein

Dosage & Administration

  • Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years
  • Maintenance Treatment: Decrease to 5 days treatment at the same daily dose with two successive medicine-free days every week
  • Peripheral Vascular Disease: 10 mg twice daily, up to 30 mg per day if required
  • Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg)
  • Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy

Interactions

  • Galactorrhoea reported in few women on oral contraceptives within the first two months of Norium treatment
  • Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Norium by increasing its metabolism

Contraindications

  • Hypersensitivity to Flunarizine
  • Contra-indicated in patients with a history of depressive illness or pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders

Side Effects

  • Drowsiness and/or fatigue
  • Weight gain and/or increased appetite
  • Adverse experiences: depression, extrapyramidal symptoms, heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache, skin rash

Pregnancy & Lactation

  • Safety in pregnancy and lactation has not been established

Precautions & Warnings

  • May lead to drowsiness aggravated by simultaneous intake of alcohol or other central nervous system depressants
  • Patients cautioned against driving motor vehicles or performing other potentially hazardous tasks
  • Not suited for aborting a migraine attack
  • May give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism

Therapeutic Class

  • Miscellaneous prophylactic migraine preparations

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture, keep out of the reach of children

Related Brands