Rizelium 10 mg (Capsule)

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)

Strip Price: ৳ 50.00

Medicine Details

Category	Details
Generic	Flunarizine
Company	Unimed unihealth pharmaceuticals ltd
Also available as	Rizelium 5 mg capsule

Indications

Prophylaxis of classic (with aura) or common (without aura) migraine
Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
Peripheral Vascular Disease (PVD)
Motion sickness
Refractory epilepsy resistant to conventional antiepileptic therapy

Pharmacology

Selective calcium channel antagonist, antihistaminic and sedative properties, 99% plasma protein binding affinity

Dosage & Administration

Migraine Prophylaxis starting dose: 10 mg at night in patients less than 65 years of age
Migraine Prophylaxis maintenance treatment: 5 days treatment with two successive medicine free days every week
Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
Vertigo & motion sickness: 10-20 mg daily for adults, 5 mg daily for children (>40 kg)
Epileptic seizure: 15-20 mg daily in adults, 5 to 10 mg daily for children as an add-on therapy

Interaction

Galactorrhoea reported in few women on oral contraceptives within the first two months of Rizelium treatment, hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Rizelium

Contraindications

Hypersensitivity to Flunarizine, history of depressive illness, pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders

Side Effects

Drowsiness and/or fatigue
Weight gain and/or increased appetite
Depression, extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor)
Heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhoea, dry mouth, muscle ache, skin rash

Pregnancy & Lactation

Safety in pregnancy and lactation not established

Precautions & Warnings

May lead to drowsiness aggravated by alcohol or other central nervous system depressants
Patients cautioned against driving or performing other potentially hazardous tasks
Not suited for aborting a migraine attack
Possible occurrence of an attack is no reason to increase the dose
May give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly