Migrium 5 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Flunarizine
Company Osl pharma limited
Also available as

Indications

  • Prophylaxis of classic (with aura) or common (without aura) migraine
  • Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
  • Peripheral Vascular Disease (PVD)
  • Motion sickness
  • Refractory epilepsy resistant to conventional antiepileptic therapy

Pharmacology

  • Flunarizine is the difluorinated derivative of cinnarizine
  • Selective calcium channel antagonist
  • Reduces excessive transmembrane influx of calcium
  • Prevents cellular calcium overload
  • Has some antihistaminic and sedative properties

Dosage & Administration

  • Migraine Prophylaxis: Starting Dose 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years
  • Maintenance Treatment: Dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week
  • Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
  • Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg)
  • Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy

Interaction

  • Galactorrhoea reported in few women on oral contraceptives within the first two months of Migrium treatment
  • Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Migrium by increasing its metabolism

Contraindications

  • Hypersensitivity to Flunarizine
  • Contra-indicated in patients with a history of depressive illness
  • Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders

Side Effects

  • Drowsiness and/or fatigue
  • Weight gain and/or increased appetite
  • Depression (female patients with a history of depressive illness may be particularly at risk)
  • Extrapyramidal symptoms (bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor)
  • Heartburn
  • Nausea
  • Gastralgia
  • Insomnia
  • Anxiety
  • Galactorrhoea
  • Dry mouth
  • Muscle ache
  • Skin rash

Pregnancy & Lactation

  • Safety in pregnancy and lactation has not been established

Precautions & Warnings

  • May lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants
  • Not suited for aborting a migraine attack
  • Extrapyramidal and depressive symptoms may occur
  • May reveal Parkinsonism, especially in predisposed patients such as the elderly

Therapeutic Class

  • Miscellaneous prophylactic migraine preparations

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light & moisture
  • Keep out of the reach of children

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