Migrium 5 mg (Tablet)
Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00
Medicine Details
Category | Details |
---|---|
Generic | Flunarizine |
Company | Osl pharma limited |
Also available as |
Indications
- Prophylaxis of classic (with aura) or common (without aura) migraine
- Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system)
- Peripheral Vascular Disease (PVD)
- Motion sickness
- Refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is the difluorinated derivative of cinnarizine
- Selective calcium channel antagonist
- Reduces excessive transmembrane influx of calcium
- Prevents cellular calcium overload
- Has some antihistaminic and sedative properties
Dosage & Administration
- Migraine Prophylaxis: Starting Dose 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years
- Maintenance Treatment: Dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg)
- Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
Interaction
- Galactorrhoea reported in few women on oral contraceptives within the first two months of Migrium treatment
- Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Migrium by increasing its metabolism
Contraindications
- Hypersensitivity to Flunarizine
- Contra-indicated in patients with a history of depressive illness
- Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Depression (female patients with a history of depressive illness may be particularly at risk)
- Extrapyramidal symptoms (bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor)
- Heartburn
- Nausea
- Gastralgia
- Insomnia
- Anxiety
- Galactorrhoea
- Dry mouth
- Muscle ache
- Skin rash
Pregnancy & Lactation
- Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants
- Not suited for aborting a migraine attack
- Extrapyramidal and depressive symptoms may occur
- May reveal Parkinsonism, especially in predisposed patients such as the elderly
Therapeutic Class
- Miscellaneous prophylactic migraine preparations
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children