Migrium 10 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Osl pharma limited |
| Also available as |
Indications
- Prophylaxis of classic (with aura) or common (without aura) migraine
- Symptomatic treatment of vestibular vertigo
- Peripheral Vascular Disease (PVD)
- Motion sickness
- Refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is the difluorinated derivative of cinnarizine
- Selective calcium channel antagonist
- Reduces excessive transmembrane influx of calcium
- Prevents cellular calcium overload
- Has antihistaminic and sedative properties
- Binds to plasma protein
Dosage & Administration
- Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years
- Maintenance Treatment
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children
- Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
Interaction
- Galactorrhoea reported in some women on oral contraceptives within the first two months of Migrium treatment
- Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Migrium
- Increase in dosage of Migrium may be required
Contraindications
- Hypersensitivity to Flunarizine
- Contra-indicated in patients with a history of depressive illness
- Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Depression
- Extrapyramidal symptoms
- Heartburn
- Nausea
- Gastralgia
- Insomnia
- Anxiety
- Galactorrhoea
- Dry mouth
- Muscle ache
- Skin rash
Pregnancy & Lactation
- Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness
- Aggravated by simultaneous intake of alcohol or other central nervous system depressants
- Not suited for aborting a migraine attack
- Extrapyramidal and depressive symptoms may occur
- Reveals Parkinsonism, especially in predisposed patients
- Should be used with caution in predisposed patients
Therapeutic Class
- Miscellaneous prophylactic migraine preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children