Dex-i 300 mg (Tablet)

Indications

• Relief of osteoarthritis symptoms
• Rheumatoidal disorders treatment
• Painful menstruation relief
• Treatment of common headache and fever
• Symptomatic treatment of mild to moderate pain
• Adjuvant for common cold and influenza

Pharmacology

• Non-steroidal anti-inflammatory drug
• Analgesic action
• Inhibits prostaglandin synthesis
• Absorbed from the small intestine
• Metabolic transformation in the liver
• Plasma protein binding of about 99%
• Maximum plasma levels reached in 2 hours after oral administration

Dosage & Administration

• Dosage adjusted to seriousness of syndrome and patient complaints
• Recommended dosage: 600-900 mg per day, at 2-3 divided doses
• Temporary raise of dosage up to 1200 mg per day for acute disorders
• Maximum daily dose is 1200 mg
• Dosage for dysmenorrhea: 600-900 mg per day

Interaction

• Interacts with anticoagulant, hydantoine, sulfonamide, ticlopidine, lithium, other NSAID's, ACE inhibitors, beta blockers, cyclosporine, tacrolimus, corticosteroids, digoxin, methotrexate, pentoxyfiline, phenytoine, probenecid, sulfinpyrazon, sulfonylurea, thiazide and thiazide type diuretics, zidovudine

Contraindications

• Contraindicated in patients with hypersensitivity to dexibuprofen or NSAIDs
• Contraindicated in patients with active or suspected hemorrhage, serious heart diseases, kidney function impairment, and liver function impairment

Side Effects

• Common side-effects: dyspepsia, diarrhea, fatigue, headache, nausea, vomiting, abdominal pain, hypersensitivity reactions

Pregnancy & Lactation

• Avoid use during pregnancy
• Use with caution in nursing mothers

Precautions & Warnings

• Use with caution in patients with bronchial asthma or chronic pulmonary diseases
• Caution in patients with hepatic, renal, or cardiac insufficiency and hypertension
• Extreme caution in hemorrhagic conditions and allergic patients

Use in Special Populations

• Caution in patients with hepatic and renal impairment
• Specific dosage considerations for children and elderly people

Overdose Effects

• Low acute toxicities
• Symptoms occur at doses between 80 and 100 mg/kg body weight
• Mild to serious symptoms, including abdominal pain, nausea, vomiting, lethargy, hypotension, coma
• No specific antidote, treatment must be symptomatic

Therapeutic Class

• Drugs for osteoarthritis
• Drugs for rheumatoid arthritis
• Non-steroidal anti-inflammatory drugs (NSAIDs)

Storage Conditions

• Do not store above 30°C
• Keep away from light and out of the reach of children

Related Brands

• Artoflex 300 mg (Tablet) - opsonin-pharma-ltd