Fluracedyl 25 mg/ml (IV Injection or Infusion)

500 mg vial: ৳ 450.00

Medicine Details

Category Details
Generic Fluorouracil
Company Pharmachemie bv

Indications

  • Carcinoma of the colon or rectum
  • Carcinoma of the stomach and exocrine pancreas
  • Carcinoma of the liver
  • Carcinoma of the breast
  • Carcinoma of the bladder
  • Carcinoma of the lung
  • Epithelial ovarian carcinoma
  • Cervical carcinoma

Pharmacology

  • Conversion to active 5-fluorodeoxyuridine monophosphate (FdUMP)
  • Inhibition of thymidylate kinase
  • Reduction in thymidine formation
  • Inactivation of thymidylate kinase
  • Incorporation into RNA
  • Limited effect on proliferative phase cells
  • Potential effects on G2 and S phase cells

Dosage & Administration

  • Intravenous delivery by rapid bolus injection or slow infusion
  • Daily dosage of 12-13.5 mg/kg for 5 days at 4-week intervals
  • Additional dosing for palliative management and poor risk patients
  • Maintenance therapy options
  • Usage for cervical cancer and pediatric malignant disease
  • Intra-arterial infusion and combination with radiation or other anticancer drugs

Interaction

  • Increased plasma concentrations with pre-treatment using cimetidine
  • Potential hepatic enzyme inhibition and reduced hepatic blood flow

Contraindications

  • Severe debilitation or bone marrow suppression patients
  • Pregnant or breastfeeding women
  • Non-malignant illness patients

Side Effects

  • Potentially life-threatening effects related to dosage and duration
  • Cardiac effects including ischemic cardiac events
  • Hematological effects and potential toxicity exacerbation factors
  • Neurological effects and rare syndromes
  • Other effects including allergic reactions, reduced bone marrow function, hand-foot syndrome, vomiting, diarrhea, rash, and conjunctivitis

Pregnancy & Lactation

  • Contraindicated throughout pregnancy
  • Risk of teratogenesis in first trimester
  • Inhibition of DNA, RNA, and protein synthesis for nursing mothers

Precautions & Warnings

  • Highly toxic with narrow safety margin
  • Careful supervision and monitoring for toxicity signs
  • Specific toxicity-related discontinuation criteria

Use in Special Populations

  • No dosage recommendations for neonates
  • Safety and effectiveness not established in children
  • No special precautions for the elderly

Overdose Effects

  • Deliberate overdose cases unknown
  • Supportive care for excessive toxicity
  • Qualitatively similar symptoms to side effects

Reconstitution

  • Handling and reconstitution by special trained personnel
  • Room and work surface precautions
  • Protective equipment for handling
  • Prompt skin and mucous membrane washing in case of exposure
  • Warning pregnant women against handling
  • Disposal of waste as per regulations

Storage Conditions

  • Store in original carton below 25℃
  • Protection from light, no refrigeration

Related Brands